# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on transcribed:T, untranscribed:U, bitranscribed:B and nontranscribed:N strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
T:A[C>A]A	87.333
U:A[C>A]A	48.0
B:A[C>A]A	0.0
N:A[C>A]A	325.667
T:A[C>A]C	6.333
U:A[C>A]C	2.333
B:A[C>A]C	0.0
N:A[C>A]C	46.333
T:A[C>A]G	1.333
U:A[C>A]G	0.0
B:A[C>A]G	0.0
N:A[C>A]G	11.333
T:A[C>A]T	52.0
U:A[C>A]T	38.667
B:A[C>A]T	0.333
N:A[C>A]T	233.0
T:A[C>G]A	0.333
U:A[C>G]A	0.333
B:A[C>G]A	0.0
N:A[C>G]A	11.333
T:A[C>G]C	0.333
U:A[C>G]C	0.0
B:A[C>G]C	0.0
N:A[C>G]C	14.667
T:A[C>G]G	0.667
U:A[C>G]G	1.0
B:A[C>G]G	0.0
N:A[C>G]G	6.333
T:A[C>G]T	34.0
U:A[C>G]T	49.0
B:A[C>G]T	0.0
N:A[C>G]T	164.0
T:A[C>T]A	0.333
U:A[C>T]A	0.333
B:A[C>T]A	0.0
N:A[C>T]A	12.667
T:A[C>T]C	2.667
U:A[C>T]C	1.333
B:A[C>T]C	0.0
N:A[C>T]C	33.667
T:A[C>T]G	9.333
U:A[C>T]G	9.333
B:A[C>T]G	0.0
N:A[C>T]G	57.667
T:A[C>T]T	12.667
U:A[C>T]T	9.667
B:A[C>T]T	0.0
N:A[C>T]T	66.0
T:A[T>A]A	217.0
U:A[T>A]A	105.333
B:A[T>A]A	0.333
N:A[T>A]A	549.333
T:A[T>A]C	44.667
U:A[T>A]C	22.0
B:A[T>A]C	0.0
N:A[T>A]C	136.333
T:A[T>A]G	51.0
U:A[T>A]G	24.333
B:A[T>A]G	0.0
N:A[T>A]G	156.0
T:A[T>A]T	109.667
U:A[T>A]T	65.333
B:A[T>A]T	0.0
N:A[T>A]T	320.667
T:A[T>C]A	2993.667
U:A[T>C]A	601.667
B:A[T>C]A	31.0
N:A[T>C]A	2853.667
T:A[T>C]C	79.667
U:A[T>C]C	30.667
B:A[T>C]C	0.0
N:A[T>C]C	172.0
T:A[T>C]G	422.667
U:A[T>C]G	156.333
B:A[T>C]G	2.0
N:A[T>C]G	751.667
T:A[T>C]T	1337.333
U:A[T>C]T	305.333
B:A[T>C]T	9.0
N:A[T>C]T	1395.333
T:A[T>G]A	64.667
U:A[T>G]A	49.0
B:A[T>G]A	0.333
N:A[T>G]A	204.667
T:A[T>G]C	15.667
U:A[T>G]C	14.667
B:A[T>G]C	0.0
N:A[T>G]C	43.667
T:A[T>G]G	6.667
U:A[T>G]G	2.333
B:A[T>G]G	0.0
N:A[T>G]G	35.667
T:A[T>G]T	45.667
U:A[T>G]T	45.667
B:A[T>G]T	0.0
N:A[T>G]T	127.0
T:C[C>A]A	54.0
U:C[C>A]A	39.0
B:C[C>A]A	0.0
N:C[C>A]A	249.667
T:C[C>A]C	42.0
U:C[C>A]C	29.333
B:C[C>A]C	0.0
N:C[C>A]C	195.333
T:C[C>A]G	1.333
U:C[C>A]G	0.333
B:C[C>A]G	0.0
N:C[C>A]G	10.333
T:C[C>A]T	6.667
U:C[C>A]T	3.667
B:C[C>A]T	0.0
N:C[C>A]T	55.0
T:C[C>G]A	2.667
U:C[C>G]A	2.667
B:C[C>G]A	0.0
N:C[C>G]A	32.667
T:C[C>G]C	3.667
U:C[C>G]C	4.0
B:C[C>G]C	0.0
N:C[C>G]C	32.667
T:C[C>G]G	0.667
U:C[C>G]G	1.667
B:C[C>G]G	0.0
N:C[C>G]G	7.333
T:C[C>G]T	23.667
U:C[C>G]T	38.333
B:C[C>G]T	0.0
N:C[C>G]T	117.667
T:C[C>T]A	27.0
U:C[C>T]A	24.333
B:C[C>T]A	0.0
N:C[C>T]A	115.667
T:C[C>T]C	3.667
U:C[C>T]C	2.667
B:C[C>T]C	0.0
N:C[C>T]C	31.0
T:C[C>T]G	0.0
U:C[C>T]G	0.0
B:C[C>T]G	0.0
N:C[C>T]G	0.333
T:C[C>T]T	89.0
U:C[C>T]T	88.333
B:C[C>T]T	0.0
N:C[C>T]T	317.0
T:C[T>A]A	29.333
U:C[T>A]A	18.333
B:C[T>A]A	0.0
N:C[T>A]A	108.333
T:C[T>A]C	38.333
U:C[T>A]C	18.0
B:C[T>A]C	0.0
N:C[T>A]C	117.333
T:C[T>A]G	1.667
U:C[T>A]G	1.667
B:C[T>A]G	0.0
N:C[T>A]G	22.333
T:C[T>A]T	57.0
U:C[T>A]T	40.333
B:C[T>A]T	0.0
N:C[T>A]T	211.667
T:C[T>C]A	73.0
U:C[T>C]A	38.333
B:C[T>C]A	0.333
N:C[T>C]A	194.333
T:C[T>C]C	11.667
U:C[T>C]C	3.667
B:C[T>C]C	0.0
N:C[T>C]C	46.0
T:C[T>C]G	36.333
U:C[T>C]G	22.0
B:C[T>C]G	0.0
N:C[T>C]G	113.667
T:C[T>C]T	109.667
U:C[T>C]T	52.0
B:C[T>C]T	0.333
N:C[T>C]T	256.667
T:C[T>G]A	16.0
U:C[T>G]A	12.333
B:C[T>G]A	0.333
N:C[T>G]A	57.0
T:C[T>G]C	0.667
U:C[T>G]C	1.667
B:C[T>G]C	0.0
N:C[T>G]C	4.333
T:C[T>G]G	2.667
U:C[T>G]G	1.667
B:C[T>G]G	0.0
N:C[T>G]G	17.0
T:C[T>G]T	10.667
U:C[T>G]T	10.0
B:C[T>G]T	0.0
N:C[T>G]T	36.333
T:G[C>A]A	37.667
U:G[C>A]A	26.667
B:G[C>A]A	0.0
N:G[C>A]A	163.333
T:G[C>A]C	17.333
U:G[C>A]C	9.333
B:G[C>A]C	0.0
N:G[C>A]C	77.333
T:G[C>A]G	1.667
U:G[C>A]G	0.667
B:G[C>A]G	0.0
N:G[C>A]G	12.333
T:G[C>A]T	19.333
U:G[C>A]T	14.0
B:G[C>A]T	0.0
N:G[C>A]T	103.333
T:G[C>G]A	0.0
U:G[C>G]A	0.0
B:G[C>G]A	0.0
N:G[C>G]A	1.667
T:G[C>G]C	3.667
U:G[C>G]C	5.333
B:G[C>G]C	0.0
N:G[C>G]C	30.333
T:G[C>G]G	0.0
U:G[C>G]G	0.0
B:G[C>G]G	0.0
N:G[C>G]G	0.0
T:G[C>G]T	3.0
U:G[C>G]T	2.667
B:G[C>G]T	0.0
N:G[C>G]T	27.667
T:G[C>T]A	19.333
U:G[C>T]A	18.667
B:G[C>T]A	0.0
N:G[C>T]A	100.667
T:G[C>T]C	10.0
U:G[C>T]C	10.333
B:G[C>T]C	0.0
N:G[C>T]C	61.0
T:G[C>T]G	0.333
U:G[C>T]G	0.333
B:G[C>T]G	0.0
N:G[C>T]G	6.0
T:G[C>T]T	21.333
U:G[C>T]T	22.667
B:G[C>T]T	0.0
N:G[C>T]T	102.333
T:G[T>A]A	0.667
U:G[T>A]A	0.0
B:G[T>A]A	0.0
N:G[T>A]A	8.667
T:G[T>A]C	0.333
U:G[T>A]C	0.333
B:G[T>A]C	0.0
N:G[T>A]C	3.0
T:G[T>A]G	19.0
U:G[T>A]G	13.333
B:G[T>A]G	0.0
N:G[T>A]G	96.333
T:G[T>A]T	0.333
U:G[T>A]T	0.0
B:G[T>A]T	0.0
N:G[T>A]T	11.0
T:G[T>C]A	4.333
U:G[T>C]A	2.333
B:G[T>C]A	0.0
N:G[T>C]A	36.333
T:G[T>C]C	1.0
U:G[T>C]C	0.333
B:G[T>C]C	0.0
N:G[T>C]C	14.333
T:G[T>C]G	10.0
U:G[T>C]G	7.333
B:G[T>C]G	0.0
N:G[T>C]G	55.667
T:G[T>C]T	4.333
U:G[T>C]T	2.667
B:G[T>C]T	0.0
N:G[T>C]T	41.0
T:G[T>G]A	0.333
U:G[T>G]A	0.0
B:G[T>G]A	0.0
N:G[T>G]A	2.333
T:G[T>G]C	0.333
U:G[T>G]C	0.333
B:G[T>G]C	0.0
N:G[T>G]C	5.0
T:G[T>G]G	0.0
U:G[T>G]G	0.333
B:G[T>G]G	0.0
N:G[T>G]G	0.667
T:G[T>G]T	7.333
U:G[T>G]T	10.0
B:G[T>G]T	0.0
N:G[T>G]T	39.0
T:T[C>A]A	61.667
U:T[C>A]A	48.667
B:T[C>A]A	0.0
N:T[C>A]A	244.0
T:T[C>A]C	29.667
U:T[C>A]C	20.667
B:T[C>A]C	0.0
N:T[C>A]C	121.667
T:T[C>A]G	0.667
U:T[C>A]G	0.333
B:T[C>A]G	0.0
N:T[C>A]G	11.0
T:T[C>A]T	41.0
U:T[C>A]T	43.333
B:T[C>A]T	0.0
N:T[C>A]T	198.0
T:T[C>G]A	1.667
U:T[C>G]A	2.667
B:T[C>G]A	0.0
N:T[C>G]A	29.667
T:T[C>G]C	10.0
U:T[C>G]C	10.0
B:T[C>G]C	0.0
N:T[C>G]C	65.333
T:T[C>G]G	0.0
U:T[C>G]G	0.333
B:T[C>G]G	0.0
N:T[C>G]G	0.333
T:T[C>G]T	112.333
U:T[C>G]T	234.333
B:T[C>G]T	0.333
N:T[C>G]T	513.333
T:T[C>T]A	23.667
U:T[C>T]A	24.667
B:T[C>T]A	0.0
N:T[C>T]A	107.333
T:T[C>T]C	5.0
U:T[C>T]C	6.333
B:T[C>T]C	0.0
N:T[C>T]C	42.333
T:T[C>T]G	1.0
U:T[C>T]G	2.0
B:T[C>T]G	0.0
N:T[C>T]G	19.667
T:T[C>T]T	94.0
U:T[C>T]T	129.0
B:T[C>T]T	0.0
N:T[C>T]T	399.333
T:T[T>A]A	80.0
U:T[T>A]A	69.667
B:T[T>A]A	0.0
N:T[T>A]A	311.333
T:T[T>A]C	23.333
U:T[T>A]C	16.667
B:T[T>A]C	0.333
N:T[T>A]C	114.0
T:T[T>A]G	18.0
U:T[T>A]G	19.333
B:T[T>A]G	0.0
N:T[T>A]G	107.667
T:T[T>A]T	27.667
U:T[T>A]T	27.0
B:T[T>A]T	0.0
N:T[T>A]T	149.667
T:T[T>C]A	73.0
U:T[T>C]A	55.333
B:T[T>C]A	0.333
N:T[T>C]A	262.333
T:T[T>C]C	12.333
U:T[T>C]C	7.0
B:T[T>C]C	0.0
N:T[T>C]C	62.0
T:T[T>C]G	27.333
U:T[T>C]G	24.667
B:T[T>C]G	0.0
N:T[T>C]G	124.667
T:T[T>C]T	29.333
U:T[T>C]T	25.667
B:T[T>C]T	0.0
N:T[T>C]T	143.0
T:T[T>G]A	43.0
U:T[T>G]A	52.667
B:T[T>G]A	0.667
N:T[T>G]A	158.0
T:T[T>G]C	11.667
U:T[T>G]C	16.0
B:T[T>G]C	0.0
N:T[T>G]C	50.667
T:T[T>G]G	12.667
U:T[T>G]G	9.667
B:T[T>G]G	0.0
N:T[T>G]G	56.0
T:T[T>G]T	75.667
U:T[T>G]T	94.333
B:T[T>G]T	0.333
N:T[T>G]T	211.667

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Transcribed_real_count	UnTranscribed_real_count	NonTranscribed_real_count	Transcribed_mean_sims_count	UnTranscribed_mean_sims_count	NonTranscribed_mean_sims_count	transcribed_versus_untranscribed_p_value	transcribed_versus_untranscribed_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Transcribed_real_count.1	Transcribed_mean_sims_count.1	Transcribed_min_sims_count	Transcribed_max_sims_count	Transcribed_sims_count_list	UnTranscribed_real_count.1	UnTranscribed_mean_sims_count.1	UnTranscribed_min_sims_count	UnTranscribed_max_sims_count	UnTranscribed_sims_count_list	NonTranscribed_real_count.1	NonTranscribed_mean_sims_count.1	NonTranscribed_min_sims_count	NonTranscribed_max_sims_count	NonTranscribed_sims_count_list
ESCC	SBS16	C>A	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	3463.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
ESCC	SBS16	C>G	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	3463.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
ESCC	SBS16	C>T	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	3463.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
ESCC	SBS16	T>A	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	3463.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
ESCC	SBS16	T>C	1928.0	300.0	1235.0	723.07	699.27	2022.31	5.161338296313379e-122	1.0434397868808138e-120	100.0	3463.0	Transcribed	6.427	1.034	6.215	1	1	1	1	1	1	1928.0	723.07	648.0	777.0	[721, 683, 734, 705, 695, 738, 714, 721, 689, 744, 736, 737, 690, 732, 753, 722, 754, 698, 702, 676, 738, 727, 717, 712, 721, 700, 681, 723, 708, 759, 752, 729, 760, 734, 748, 751, 726, 776, 743, 740, 712, 648, 729, 667, 772, 671, 725, 734, 750, 690, 702, 774, 760, 745, 703, 675, 701, 775, 705, 730, 704, 730, 687, 694, 750, 729, 759, 763, 716, 756, 750, 692, 722, 697, 721, 719, 730, 694, 685, 710, 732, 777, 682, 699, 711, 716, 742, 730, 706, 731, 739, 711, 723, 736, 740, 748, 751, 730, 706, 732]	300.0	699.27	634.0	743.0	[697, 678, 716, 696, 723, 705, 689, 688, 730, 671, 668, 676, 716, 713, 697, 740, 728, 688, 681, 705, 708, 740, 670, 728, 683, 707, 743, 688, 727, 688, 689, 741, 702, 720, 703, 686, 701, 657, 667, 722, 667, 714, 649, 732, 696, 719, 678, 637, 721, 703, 728, 706, 671, 687, 713, 715, 702, 697, 701, 693, 701, 681, 721, 729, 702, 686, 685, 679, 634, 671, 687, 720, 695, 665, 704, 725, 732, 715, 700, 689, 666, 698, 723, 674, 728, 730, 673, 678, 678, 711, 727, 716, 704, 675, 684, 723, 724, 697, 704, 689]	1235.0	2022.31	1966.0	2098.0	[2027, 2079, 1992, 2040, 2021, 1999, 2045, 2031, 2025, 2030, 2049, 2031, 2039, 2004, 1990, 1979, 1966, 2060, 2057, 2061, 1996, 1978, 2062, 2004, 2037, 2040, 2022, 2038, 2008, 2003, 2006, 1976, 1984, 1996, 1999, 2001, 2013, 2014, 2034, 1980, 2066, 2089, 2062, 2050, 1978, 2053, 2038, 2068, 1979, 2048, 2012, 1969, 2015, 2013, 2030, 2052, 2045, 1971, 2041, 2023, 2041, 2036, 2037, 2014, 2002, 2029, 2001, 2003, 2098, 2011, 2009, 2035, 2027, 2078, 2021, 2003, 1980, 2034, 2060, 2045, 2044, 1972, 2040, 2070, 2002, 1994, 2026, 2037, 2058, 2009, 1975, 2023, 2019, 2028, 2026, 1976, 1973, 2017, 2035, 2025]
ESCC	SBS16	T>G	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	3463.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Liver-HCC	SBS16	C>A	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	3127.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Liver-HCC	SBS16	C>G	32.0	81.0	87.0	41.05	44.62	115.26	0.004777162024362888	0.018207995965370996	6.396	3127.0	Untranscribed	2.531	1.087	2.329	1	1	1	1	1	1	32.0	41.05	26.0	57.0	[33, 43, 41, 33, 37, 41, 35, 43, 43, 55, 36, 44, 40, 32, 40, 46, 39, 47, 46, 57, 38, 34, 38, 43, 40, 47, 42, 43, 45, 47, 40, 33, 39, 39, 43, 38, 42, 51, 41, 36, 40, 43, 36, 35, 35, 52, 44, 48, 39, 42, 34, 38, 46, 26, 32, 46, 36, 39, 35, 42, 50, 37, 38, 41, 42, 42, 36, 51, 49, 38, 46, 41, 37, 51, 43, 33, 44, 37, 39, 36, 44, 34, 42, 50, 35, 42, 43, 41, 41, 44, 41, 46, 37, 46, 41, 49, 41, 29, 43, 47]	81.0	44.62	29.0	64.0	[46, 40, 37, 41, 42, 51, 36, 47, 52, 44, 51, 46, 42, 41, 44, 49, 51, 34, 47, 46, 44, 46, 46, 45, 44, 47, 43, 46, 47, 41, 42, 47, 46, 39, 49, 44, 41, 38, 46, 50, 44, 57, 50, 46, 46, 40, 42, 39, 39, 50, 44, 40, 33, 64, 52, 33, 55, 47, 44, 36, 39, 44, 52, 37, 46, 48, 48, 38, 49, 49, 47, 39, 50, 29, 53, 44, 43, 41, 51, 44, 39, 47, 48, 42, 49, 50, 43, 33, 53, 39, 39, 45, 54, 45, 50, 36, 46, 52, 42, 40]	87.0	115.26	99.0	130.0	[121, 117, 122, 127, 121, 108, 130, 111, 108, 102, 113, 112, 118, 127, 116, 110, 111, 121, 108, 99, 119, 120, 116, 116, 116, 108, 117, 113, 108, 113, 118, 120, 115, 124, 109, 118, 117, 111, 113, 116, 116, 101, 116, 121, 119, 109, 117, 113, 123, 108, 123, 122, 121, 110, 116, 122, 111, 114, 122, 122, 112, 119, 112, 122, 112, 111, 117, 113, 105, 113, 108, 120, 114, 120, 104, 123, 115, 123, 110, 121, 119, 119, 111, 113, 117, 110, 117, 127, 106, 118, 121, 110, 109, 110, 109, 118, 113, 120, 115, 115]
Liver-HCC	SBS16	C>T	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	3127.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Liver-HCC	SBS16	T>A	54.0	24.0	80.0	33.45	31.51	90.78	0.038299692329439784	0.12333952783651583	5.053	3127.0	Transcribed	2.25	1.062	2.12	1	1	1	1	1	1	54.0	33.45	16.0	48.0	[35, 27, 37, 31, 20, 34, 22, 37, 16, 33, 39, 30, 37, 29, 31, 30, 40, 33, 37, 32, 31, 31, 36, 38, 38, 26, 36, 37, 34, 31, 29, 43, 31, 30, 33, 30, 30, 31, 34, 35, 27, 34, 32, 26, 35, 31, 37, 40, 33, 42, 45, 40, 27, 37, 27, 43, 29, 45, 38, 32, 37, 27, 40, 37, 36, 37, 27, 36, 33, 28, 26, 28, 36, 31, 37, 31, 27, 32, 40, 40, 30, 37, 36, 28, 36, 33, 32, 32, 37, 39, 48, 30, 33, 30, 35, 30, 34, 34, 35, 36]	24.0	31.51	22.0	45.0	[27, 29, 31, 36, 45, 32, 40, 32, 31, 37, 34, 33, 38, 32, 28, 24, 25, 34, 30, 27, 35, 40, 29, 30, 31, 44, 30, 40, 24, 25, 32, 34, 27, 32, 37, 40, 39, 30, 41, 26, 22, 39, 27, 33, 27, 32, 34, 29, 32, 37, 26, 28, 34, 27, 36, 27, 26, 22, 31, 34, 28, 32, 34, 28, 24, 27, 33, 32, 33, 29, 32, 35, 26, 26, 31, 31, 36, 42, 31, 30, 31, 30, 36, 30, 30, 31, 36, 32, 30, 30, 28, 30, 32, 28, 25, 39, 31, 30, 29, 29]	80.0	90.78	79.0	108.0	[95, 99, 88, 90, 91, 90, 93, 86, 108, 85, 82, 92, 81, 94, 96, 101, 91, 89, 89, 96, 89, 85, 90, 87, 87, 86, 90, 81, 97, 100, 94, 79, 98, 94, 86, 87, 87, 94, 81, 95, 106, 82, 96, 97, 93, 93, 85, 86, 91, 79, 84, 88, 94, 93, 92, 85, 101, 89, 86, 90, 91, 96, 86, 90, 96, 91, 96, 88, 91, 98, 97, 94, 93, 98, 89, 94, 94, 82, 85, 85, 95, 88, 84, 97, 89, 92, 87, 91, 90, 86, 81, 95, 90, 97, 98, 86, 91, 92, 92, 90]
Liver-HCC	SBS16	T>C	1806.0	183.0	708.0	559.18	556.85	1567.2	6.247103289080215e-141	1.3735119507761772e-139	86.249	3127.0	Transcribed	9.869	1.004	9.828	1	1	1	1	1	1	1806.0	559.18	509.0	620.0	[572, 552, 536, 605, 575, 565, 549, 529, 563, 574, 542, 572, 578, 612, 572, 581, 537, 540, 551, 557, 570, 540, 569, 554, 577, 558, 545, 600, 563, 541, 568, 553, 569, 533, 509, 547, 579, 620, 524, 549, 586, 530, 554, 571, 556, 561, 577, 519, 559, 553, 536, 566, 547, 530, 564, 571, 581, 551, 525, 526, 603, 547, 552, 585, 539, 519, 578, 558, 563, 548, 565, 552, 584, 598, 576, 552, 577, 529, 526, 550, 543, 520, 559, 559, 592, 538, 545, 548, 528, 555, 555, 575, 576, 600, 602, 559, 577, 564, 556, 573]	183.0	556.85	502.0	613.0	[562, 556, 567, 568, 543, 567, 513, 560, 577, 533, 551, 533, 574, 555, 536, 575, 579, 593, 528, 534, 542, 533, 597, 556, 545, 577, 554, 558, 545, 560, 578, 544, 548, 559, 520, 550, 567, 502, 568, 580, 589, 540, 539, 549, 563, 549, 569, 554, 560, 591, 541, 511, 572, 576, 542, 583, 533, 520, 596, 543, 547, 549, 563, 568, 584, 551, 572, 562, 533, 586, 567, 534, 546, 566, 599, 580, 537, 593, 580, 551, 575, 613, 529, 555, 573, 550, 557, 562, 571, 541, 541, 564, 549, 529, 504, 542, 589, 527, 572, 567]	708.0	1567.2	1505.0	1653.0	[1550, 1572, 1583, 1511, 1568, 1552, 1624, 1590, 1543, 1573, 1590, 1578, 1533, 1514, 1574, 1536, 1566, 1551, 1607, 1587, 1571, 1609, 1515, 1567, 1564, 1547, 1581, 1530, 1572, 1587, 1538, 1585, 1577, 1590, 1653, 1597, 1537, 1563, 1589, 1550, 1508, 1612, 1587, 1560, 1560, 1577, 1541, 1607, 1564, 1541, 1605, 1600, 1562, 1576, 1574, 1528, 1567, 1614, 1562, 1609, 1537, 1586, 1568, 1532, 1558, 1610, 1531, 1562, 1591, 1547, 1564, 1592, 1552, 1523, 1505, 1547, 1568, 1560, 1573, 1583, 1562, 1556, 1595, 1571, 1521, 1601, 1585, 1571, 1585, 1587, 1586, 1547, 1561, 1554, 1577, 1585, 1515, 1591, 1561, 1542]
Liver-HCC	SBS16	T>G	25.0	12.0	35.0	14.2	13.73	42.34	0.29957223137767786	0.6676130520211274	2.303	3127.0	Transcribed	2.083	1.034	2.014	1	1	1	1	1	1	25.0	14.2	6.0	23.0	[11, 15, 12, 14, 19, 12, 11, 12, 10, 19, 15, 6, 15, 16, 16, 23, 11, 14, 15, 17, 21, 19, 11, 15, 19, 10, 17, 11, 15, 13, 14, 9, 15, 12, 9, 8, 22, 18, 17, 14, 13, 10, 14, 7, 15, 19, 9, 19, 16, 13, 16, 14, 12, 9, 14, 14, 14, 12, 15, 23, 10, 20, 15, 13, 16, 18, 15, 12, 22, 15, 12, 12, 10, 15, 14, 17, 17, 14, 14, 14, 15, 19, 14, 10, 12, 15, 8, 12, 14, 14, 13, 18, 16, 14, 22, 12, 17, 13, 10, 7]	12.0	13.73	7.0	22.0	[15, 11, 21, 15, 13, 12, 9, 13, 14, 10, 15, 11, 12, 12, 13, 13, 19, 15, 13, 15, 11, 12, 15, 14, 11, 13, 13, 12, 12, 16, 11, 21, 22, 12, 16, 11, 16, 16, 16, 17, 13, 13, 16, 11, 11, 11, 19, 12, 16, 17, 10, 16, 18, 12, 10, 18, 21, 14, 13, 13, 20, 10, 19, 18, 14, 14, 11, 15, 11, 12, 14, 12, 18, 12, 13, 13, 15, 14, 9, 7, 15, 16, 14, 17, 15, 14, 15, 11, 16, 11, 9, 11, 8, 16, 9, 13, 7, 17, 15, 11]	35.0	42.34	34.0	53.0	[44, 44, 37, 41, 38, 47, 50, 45, 46, 41, 40, 53, 43, 43, 41, 34, 40, 41, 42, 38, 39, 39, 44, 41, 41, 47, 40, 47, 43, 41, 45, 40, 35, 47, 46, 51, 34, 37, 37, 39, 44, 47, 40, 52, 44, 41, 42, 40, 38, 40, 45, 40, 40, 49, 46, 39, 35, 44, 43, 34, 40, 42, 36, 39, 40, 38, 44, 43, 37, 43, 45, 46, 42, 43, 43, 40, 38, 42, 47, 49, 40, 36, 42, 44, 43, 42, 47, 47, 42, 46, 49, 41, 46, 40, 40, 45, 46, 40, 45, 52]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change
SBS16	T>C	Transcribed	['ESCC', 'Liver-HCC']	2	['ESCC', 'Liver-HCC']	2	['ESCC', 'Liver-HCC']	2	['ESCC', 'Liver-HCC']	2	['ESCC', 'Liver-HCC']	2	['ESCC', 'Liver-HCC']	2	['ESCC', 'Liver-HCC']	2	2.0