# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 327.618 E:A[C>A]A 349.329 A:A[C>G]A 23.734 E:A[C>G]A 25.218 A:A[C>T]A 24.245 E:A[C>T]A 25.25 A:A[T>A]A 590.775 E:A[T>A]A 632.331 A:A[T>C]A 4182.371 E:A[T>C]A 4548.998 A:A[T>G]A 241.315 E:A[T>G]A 252.236 A:A[C>A]C 58.461 E:A[C>A]C 63.255 A:A[C>G]C 27.1 E:A[C>G]C 28.755 A:A[C>T]C 48.358 E:A[C>T]C 50.46 A:A[T>A]C 157.599 E:A[T>A]C 172.205 A:A[T>C]C 208.661 E:A[T>C]C 227.26 A:A[T>G]C 75.606 E:A[T>G]C 74.555 A:A[C>A]G 23.836 E:A[C>A]G 24.449 A:A[C>G]G 17.542 E:A[C>G]G 18.05 A:A[C>T]G 76.009 E:A[C>T]G 78.129 A:A[T>A]G 184.949 E:A[T>A]G 182.988 A:A[T>C]G 901.53 E:A[T>C]G 944.679 A:A[T>G]G 51.948 E:A[T>G]G 50.687 A:A[C>A]T 244.943 E:A[C>A]T 257.258 A:A[C>G]T 198.1 E:A[C>G]T 198.547 A:A[C>T]T 83.685 E:A[C>T]T 88.106 A:A[T>A]T 348.459 E:A[T>A]T 359.115 A:A[T>C]T 2027.375 E:A[T>C]T 2087.033 A:A[T>G]T 176.766 E:A[T>G]T 175.388 A:C[C>A]A 255.928 E:C[C>A]A 270.202 A:C[C>G]A 45.056 E:C[C>G]A 47.986 A:C[C>T]A 139.787 E:C[C>T]A 144.19 A:C[T>A]A 126.571 E:C[T>A]A 134.752 A:C[T>C]A 227.044 E:C[T>C]A 242.847 A:C[T>G]A 81.0 E:C[T>G]A 85.116 A:C[C>A]C 197.576 E:C[C>A]C 214.1 A:C[C>G]C 49.741 E:C[C>G]C 50.139 A:C[C>T]C 47.911 E:C[C>T]C 48.124 A:C[T>A]C 141.004 E:C[T>A]C 145.094 A:C[T>C]C 61.105 E:C[T>C]C 64.392 A:C[T>G]C 21.295 E:C[T>G]C 21.485 A:C[C>A]G 24.845 E:C[C>A]G 27.152 A:C[C>G]G 23.037 E:C[C>G]G 20.476 A:C[C>T]G 8.318 E:C[C>T]G 8.458 A:C[T>A]G 35.418 E:C[T>A]G 35.398 A:C[T>C]G 139.876 E:C[T>C]G 143.271 A:C[T>G]G 34.519 E:C[T>G]G 33.527 A:C[C>A]T 66.091 E:C[C>A]T 67.436 A:C[C>G]T 151.314 E:C[C>G]T 148.463 A:C[C>T]T 362.625 E:C[C>T]T 367.253 A:C[T>A]T 232.722 E:C[T>A]T 235.205 A:C[T>C]T 308.997 E:C[T>C]T 309.71 A:C[T>G]T 62.51 E:C[T>G]T 60.843 A:G[C>A]A 177.923 E:G[C>A]A 179.316 A:G[C>G]A 12.905 E:G[C>G]A 13.451 A:G[C>T]A 119.807 E:G[C>T]A 122.695 A:G[T>A]A 20.424 E:G[T>A]A 20.614 A:G[T>C]A 51.277 E:G[T>C]A 53.265 A:G[T>G]A 13.33 E:G[T>G]A 13.452 A:G[C>A]C 92.769 E:G[C>A]C 96.977 A:G[C>G]C 47.94 E:G[C>G]C 51.814 A:G[C>T]C 79.933 E:G[C>T]C 81.775 A:G[T>A]C 14.025 E:G[T>A]C 15.022 A:G[T>C]C 26.867 E:G[T>C]C 26.987 A:G[T>G]C 16.534 E:G[T>G]C 17.222 A:G[C>A]G 25.308 E:G[C>A]G 25.811 A:G[C>G]G 1.018 E:G[C>G]G 0.997 A:G[C>T]G 21.015 E:G[C>T]G 21.356 A:G[T>A]G 117.271 E:G[T>A]G 107.462 A:G[T>C]G 76.166 E:G[T>C]G 73.543 A:G[T>G]G 8.66 E:G[T>G]G 7.824 A:G[C>A]T 120.18 E:G[C>A]T 116.785 A:G[C>G]T 47.015 E:G[C>G]T 44.093 A:G[C>T]T 127.399 E:G[C>T]T 125.598 A:G[T>A]T 23.231 E:G[T>A]T 23.079 A:G[T>C]T 56.025 E:G[T>C]T 55.225 A:G[T>G]T 62.494 E:G[T>G]T 57.187 A:T[C>A]A 264.942 E:T[C>A]A 273.559 A:T[C>G]A 47.115 E:T[C>G]A 47.717 A:T[C>T]A 138.288 E:T[C>T]A 134.934 A:T[T>A]A 337.149 E:T[T>A]A 340.166 A:T[T>C]A 289.067 E:T[T>C]A 292.927 A:T[T>G]A 201.416 E:T[T>G]A 190.294 A:T[C>A]C 138.368 E:T[C>A]C 146.542 A:T[C>G]C 84.867 E:T[C>G]C 84.722 A:T[C>T]C 61.544 E:T[C>T]C 61.425 A:T[T>A]C 124.801 E:T[T>A]C 128.407 A:T[T>C]C 79.097 E:T[T>C]C 77.891 A:T[T>G]C 76.618 E:T[T>G]C 75.443 A:T[C>A]G 24.96 E:T[C>A]G 25.713 A:T[C>G]G 7.209 E:T[C>G]G 6.968 A:T[C>T]G 36.393 E:T[C>T]G 36.044 A:T[T>A]G 124.221 E:T[T>A]G 121.222 A:T[T>C]G 147.696 E:T[T>C]G 141.557 A:T[T>G]G 79.761 E:T[T>G]G 75.914 A:T[C>A]T 219.244 E:T[C>A]T 218.595 A:T[C>G]T 665.726 E:T[C>G]T 609.864 A:T[C>T]T 466.956 E:T[C>T]T 451.982 A:T[T>A]T 165.127 E:T[T>A]T 160.421 A:T[T>C]T 158.443 E:T[T>C]T 159.187 A:T[T>G]T 294.544 E:T[T>G]T 282.452 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list ESCC SBS16 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3134.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS16 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3134.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS16 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3134.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS16 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3134.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS16 T>C 1506.0 1628.0 1550.18 1573.13 0.2153059504812298 0.5214686125993094 100.0 3134.0 Leading 1.081 1.015 1.065 1506.0 1550.18 1489.0 1631.0 [1586, 1539, 1520, 1575, 1515, 1512, 1561, 1547, 1551, 1551, 1545, 1609, 1532, 1599, 1557, 1631, 1570, 1557, 1563, 1502, 1549, 1534, 1496, 1532, 1548, 1546, 1591, 1550, 1511, 1515, 1540, 1559, 1552, 1566, 1565, 1555, 1523, 1489, 1529, 1533, 1526, 1559, 1535, 1577, 1538, 1545, 1509, 1588, 1556, 1589, 1542, 1536, 1577, 1559, 1535, 1531, 1562, 1528, 1541, 1521, 1583, 1577, 1550, 1541, 1546, 1496, 1540, 1508, 1565, 1561, 1561, 1512, 1560, 1578, 1521, 1562, 1555, 1527, 1548, 1577, 1568, 1555, 1563, 1536, 1605, 1565, 1513, 1587, 1530, 1586, 1542, 1545, 1549, 1543, 1575, 1598, 1523, 1603, 1540, 1565] 1628.0 1573.13 1517.0 1632.0 [1522, 1596, 1611, 1540, 1612, 1619, 1547, 1585, 1559, 1571, 1580, 1540, 1592, 1535, 1578, 1527, 1574, 1523, 1568, 1618, 1591, 1593, 1632, 1591, 1587, 1545, 1527, 1581, 1578, 1602, 1559, 1541, 1583, 1553, 1586, 1569, 1578, 1615, 1596, 1594, 1612, 1562, 1571, 1556, 1604, 1581, 1628, 1526, 1578, 1543, 1575, 1568, 1553, 1537, 1564, 1596, 1552, 1557, 1608, 1604, 1533, 1548, 1569, 1575, 1587, 1609, 1603, 1606, 1570, 1569, 1590, 1595, 1574, 1571, 1606, 1531, 1575, 1601, 1541, 1560, 1548, 1575, 1559, 1555, 1517, 1571, 1590, 1556, 1601, 1531, 1617, 1587, 1562, 1579, 1544, 1538, 1588, 1536, 1613, 1560] ESCC SBS16 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3134.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS16 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2851.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS16 C>G 102.0 79.0 95.14 90.67 0.3472403293274852 0.7390137404387779 6.349 2851.0 Lagging 1.291 1.049 1.23 1 1 102.0 95.14 74.0 112.0 [97, 102, 107, 95, 96, 96, 97, 97, 97, 97, 100, 100, 102, 101, 89, 91, 92, 86, 93, 92, 89, 93, 84, 111, 111, 86, 91, 93, 94, 91, 88, 83, 112, 85, 91, 83, 92, 95, 93, 95, 108, 103, 89, 93, 86, 83, 96, 99, 87, 97, 93, 92, 95, 96, 99, 98, 96, 104, 101, 82, 97, 90, 94, 99, 94, 75, 107, 94, 93, 94, 92, 85, 104, 90, 102, 103, 104, 102, 97, 84, 106, 102, 98, 98, 88, 94, 99, 100, 98, 99, 99, 95, 99, 106, 95, 74, 108, 97, 82, 93] 79.0 90.67 75.0 108.0 [86, 85, 81, 93, 90, 87, 88, 93, 86, 86, 80, 86, 83, 86, 93, 102, 95, 99, 91, 94, 93, 92, 97, 83, 75, 103, 91, 94, 90, 94, 98, 108, 82, 101, 97, 99, 92, 95, 89, 92, 79, 88, 98, 89, 96, 91, 96, 90, 94, 94, 89, 88, 91, 90, 89, 83, 89, 83, 89, 98, 91, 98, 97, 82, 89, 107, 86, 94, 95, 92, 96, 96, 88, 93, 76, 87, 87, 90, 83, 97, 80, 89, 89, 84, 92, 92, 89, 86, 82, 82, 87, 95, 94, 83, 91, 104, 82, 91, 103, 95] Liver-HCC SBS16 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2851.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS16 T>A 64.0 80.0 72.06 71.64 0.34522694979540225 0.7359761855570347 5.051 2851.0 Leading 1.25 0.994 1.257 1 1 64.0 72.06 55.0 89.0 [79, 71, 76, 74, 71, 71, 67, 70, 75, 63, 73, 78, 89, 68, 78, 81, 72, 59, 82, 78, 79, 66, 66, 71, 75, 81, 71, 71, 77, 75, 65, 73, 55, 80, 77, 79, 74, 73, 79, 72, 79, 58, 81, 68, 78, 69, 69, 77, 68, 77, 67, 67, 62, 59, 66, 66, 72, 68, 85, 71, 67, 68, 64, 60, 69, 68, 78, 80, 76, 75, 67, 70, 73, 86, 76, 70, 75, 74, 63, 74, 65, 68, 74, 72, 74, 74, 79, 66, 78, 72, 71, 76, 67, 73, 73, 66, 78, 57, 79, 70] 80.0 71.64 57.0 90.0 [62, 72, 68, 74, 78, 73, 71, 75, 68, 80, 69, 69, 57, 75, 71, 58, 69, 81, 62, 66, 67, 81, 69, 67, 69, 64, 76, 71, 65, 69, 84, 72, 89, 62, 71, 67, 68, 65, 67, 72, 65, 86, 66, 73, 68, 74, 80, 69, 69, 59, 80, 80, 82, 86, 78, 81, 68, 76, 61, 74, 75, 77, 83, 75, 76, 71, 68, 62, 68, 62, 75, 70, 68, 60, 65, 74, 63, 68, 85, 73, 82, 73, 74, 72, 72, 73, 64, 80, 64, 75, 68, 71, 75, 71, 70, 80, 64, 90, 65, 75] Liver-HCC SBS16 T>C 1120.0 1351.0 1231.33 1239.17 0.0015664856129688936 0.0063156810246740875 86.671 2851.0 Leading 1.206 1.006 1.199 1 1 1120.0 1231.33 1161.0 1304.0 [1271, 1205, 1228, 1227, 1238, 1179, 1200, 1225, 1219, 1222, 1292, 1266, 1197, 1210, 1248, 1242, 1244, 1216, 1304, 1185, 1232, 1204, 1250, 1161, 1240, 1229, 1231, 1217, 1250, 1243, 1227, 1288, 1219, 1208, 1264, 1230, 1247, 1224, 1211, 1228, 1235, 1239, 1229, 1255, 1240, 1219, 1199, 1186, 1227, 1210, 1238, 1224, 1225, 1220, 1215, 1225, 1239, 1231, 1208, 1219, 1243, 1224, 1239, 1281, 1243, 1243, 1246, 1250, 1239, 1217, 1246, 1211, 1232, 1191, 1239, 1277, 1210, 1290, 1216, 1218, 1298, 1251, 1254, 1223, 1226, 1174, 1217, 1284, 1225, 1282, 1223, 1223, 1244, 1237, 1217, 1193, 1209, 1197, 1250, 1247] 1351.0 1239.17 1175.0 1341.0 [1204, 1254, 1245, 1234, 1253, 1288, 1233, 1248, 1242, 1255, 1177, 1191, 1264, 1258, 1223, 1227, 1207, 1254, 1175, 1281, 1237, 1273, 1224, 1341, 1225, 1240, 1249, 1256, 1242, 1249, 1233, 1188, 1250, 1241, 1209, 1257, 1219, 1244, 1297, 1246, 1229, 1227, 1224, 1228, 1218, 1241, 1277, 1249, 1239, 1247, 1204, 1267, 1239, 1234, 1257, 1243, 1244, 1256, 1268, 1251, 1223, 1236, 1255, 1175, 1227, 1210, 1206, 1201, 1234, 1258, 1214, 1266, 1248, 1256, 1216, 1219, 1271, 1189, 1248, 1265, 1189, 1235, 1229, 1255, 1275, 1277, 1242, 1192, 1231, 1191, 1261, 1261, 1243, 1232, 1264, 1279, 1248, 1277, 1231, 1213] Liver-HCC SBS16 T>G 17.0 38.0 31.81 32.86 0.06009905186406589 0.18481071703831528 1.929 2851.0 Leading 2.235 1.033 2.164 1 1 1 1 1 1 17.0 31.81 23.0 44.0 [25, 33, 24, 33, 34, 30, 29, 27, 29, 30, 37, 28, 36, 33, 31, 31, 34, 31, 44, 26, 25, 30, 31, 33, 28, 31, 23, 25, 31, 34, 24, 34, 34, 34, 25, 29, 35, 32, 32, 33, 33, 37, 37, 27, 35, 39, 33, 29, 33, 31, 31, 31, 43, 27, 32, 30, 41, 32, 31, 33, 33, 25, 35, 29, 29, 27, 31, 35, 32, 33, 34, 35, 32, 34, 34, 30, 29, 35, 33, 30, 39, 27, 33, 30, 36, 32, 34, 39, 35, 29, 33, 38, 31, 29, 35, 32, 36, 29, 27, 29] 38.0 32.86 19.0 41.0 [34, 32, 40, 35, 31, 37, 35, 39, 37, 33, 26, 34, 29, 34, 36, 36, 28, 34, 19, 41, 36, 33, 36, 32, 38, 34, 41, 36, 33, 33, 41, 36, 32, 30, 32, 31, 29, 33, 35, 33, 29, 31, 26, 38, 30, 28, 33, 36, 30, 33, 35, 36, 24, 37, 34, 35, 25, 34, 36, 29, 34, 38, 30, 37, 32, 39, 34, 30, 34, 32, 29, 30, 35, 33, 31, 35, 36, 29, 30, 32, 31, 33, 32, 32, 33, 30, 32, 28, 25, 37, 30, 29, 34, 35, 31, 29, 28, 36, 36, 32] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS16 T>C Leading ['Liver-HCC'] 1 ['Liver-HCC'] 1 [] 0 [] 0 [] 0 [] 0 ['ESCC', 'Liver-HCC'] 2 1.2