# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 376.849 E:A[C>A]A 413.823 A:A[C>G]A 62.231 E:A[C>G]A 64.797 A:A[C>T]A 285.523 E:A[C>T]A 301.736 A:A[T>A]A 561.723 E:A[T>A]A 598.214 A:A[T>C]A 5408.416 E:A[T>C]A 5802.379 A:A[T>G]A 178.543 E:A[T>G]A 187.124 A:A[C>A]C 86.293 E:A[C>A]C 94.811 A:A[C>G]C 34.969 E:A[C>G]C 37.083 A:A[C>T]C 104.194 E:A[C>T]C 111.5 A:A[T>A]C 233.355 E:A[T>A]C 245.568 A:A[T>C]C 2460.346 E:A[T>C]C 2681.467 A:A[T>G]C 47.653 E:A[T>G]C 49.456 A:A[C>A]G 40.49 E:A[C>A]G 41.324 A:A[C>G]G 3.876 E:A[C>G]G 3.768 A:A[C>T]G 11.764 E:A[C>T]G 12.07 A:A[T>A]G 266.511 E:A[T>A]G 270.281 A:A[T>C]G 3906.134 E:A[T>C]G 4033.016 A:A[T>G]G 33.525 E:A[T>G]G 33.703 A:A[C>A]T 114.019 E:A[C>A]T 119.492 A:A[C>G]T 84.684 E:A[C>G]T 84.548 A:A[C>T]T 123.453 E:A[C>T]T 128.623 A:A[T>A]T 378.556 E:A[T>A]T 393.474 A:A[T>C]T 3498.343 E:A[T>C]T 3640.422 A:A[T>G]T 114.273 E:A[T>G]T 112.992 A:C[C>A]A 559.69 E:C[C>A]A 603.334 A:C[C>G]A 70.357 E:C[C>G]A 74.159 A:C[C>T]A 551.376 E:C[C>T]A 575.06 A:C[T>A]A 84.398 E:C[T>A]A 88.9 A:C[T>C]A 3067.92 E:C[T>C]A 3225.813 A:C[T>G]A 75.197 E:C[T>G]A 78.644 A:C[C>A]C 421.053 E:C[C>A]C 456.15 A:C[C>G]C 36.986 E:C[C>G]C 38.898 A:C[C>T]C 17.257 E:C[C>T]C 17.766 A:C[T>A]C 664.576 E:C[T>A]C 698.084 A:C[T>C]C 3695.578 E:C[T>C]C 3907.995 A:C[T>G]C 93.129 E:C[T>G]C 93.891 A:C[C>A]G 68.636 E:C[C>A]G 71.005 A:C[C>G]G 7.581 E:C[C>G]G 7.581 A:C[C>T]G 1.739 E:C[C>T]G 1.77 A:C[T>A]G 202.788 E:C[T>A]G 204.5 A:C[T>C]G 2084.608 E:C[T>C]G 2097.996 A:C[T>G]G 38.306 E:C[T>G]G 36.811 A:C[C>A]T 108.793 E:C[C>A]T 111.882 A:C[C>G]T 87.735 E:C[C>G]T 86.244 A:C[C>T]T 281.593 E:C[C>T]T 287.066 A:C[T>A]T 241.32 E:C[T>A]T 239.233 A:C[T>C]T 3212.555 E:C[T>C]T 3219.496 A:C[T>G]T 32.104 E:C[T>G]T 30.67 A:G[C>A]A 141.795 E:G[C>A]A 148.603 A:G[C>G]A 28.268 E:G[C>G]A 29.022 A:G[C>T]A 326.297 E:G[C>T]A 334.492 A:G[T>A]A 72.255 E:G[T>A]A 74.25 A:G[T>C]A 5058.461 E:G[T>C]A 5187.626 A:G[T>G]A 24.066 E:G[T>G]A 24.447 A:G[C>A]C 32.447 E:G[C>A]C 33.44 A:G[C>G]C 16.792 E:G[C>G]C 17.829 A:G[C>T]C 99.93 E:G[C>T]C 103.843 A:G[T>A]C 186.964 E:G[T>A]C 195.316 A:G[T>C]C 2219.176 E:G[T>C]C 2280.953 A:G[T>G]C 16.648 E:G[T>G]C 16.567 A:G[C>A]G 29.613 E:G[C>A]G 30.005 A:G[C>G]G 3.706 E:G[C>G]G 3.964 A:G[C>T]G 4.618 E:G[C>T]G 4.738 A:G[T>A]G 227.066 E:G[T>A]G 226.782 A:G[T>C]G 2603.19 E:G[T>C]G 2543.377 A:G[T>G]G 24.56 E:G[T>G]G 23.386 A:G[C>A]T 2.036 E:G[C>A]T 2.004 A:G[C>G]T 25.534 E:G[C>G]T 24.155 A:G[C>T]T 194.049 E:G[C>T]T 194.141 A:G[T>A]T 99.426 E:G[T>A]T 101.101 A:G[T>C]T 3513.588 E:G[T>C]T 3511.179 A:G[T>G]T 18.862 E:G[T>G]T 17.718 A:T[C>A]A 357.491 E:T[C>A]A 369.459 A:T[C>G]A 77.015 E:T[C>G]A 76.618 A:T[C>T]A 476.493 E:T[C>T]A 474.022 A:T[T>A]A 438.119 E:T[T>A]A 442.589 A:T[T>C]A 6141.058 E:T[T>C]A 6193.853 A:T[T>G]A 126.257 E:T[T>G]A 124.432 A:T[C>A]C 280.79 E:T[C>A]C 290.911 A:T[C>G]C 106.4 E:T[C>G]C 101.458 A:T[C>T]C 171.088 E:T[C>T]C 170.734 A:T[T>A]C 903.283 E:T[T>A]C 930.519 A:T[T>C]C 3367.738 E:T[T>C]C 3409.529 A:T[T>G]C 61.246 E:T[T>G]C 60.685 A:T[C>A]G 35.562 E:T[C>A]G 36.091 A:T[C>G]G 11.126 E:T[C>G]G 11.176 A:T[C>T]G 3.391 E:T[C>T]G 3.252 A:T[T>A]G 289.879 E:T[T>A]G 292.226 A:T[T>C]G 2804.415 E:T[T>C]G 2679.172 A:T[T>G]G 48.785 E:T[T>G]G 46.701 A:T[C>A]T 219.805 E:T[C>A]T 219.217 A:T[C>G]T 293.952 E:T[C>G]T 272.949 A:T[C>T]T 531.952 E:T[C>T]T 513.216 A:T[T>A]T 555.722 E:T[T>A]T 548.496 A:T[T>C]T 4158.127 E:T[T>C]T 4106.802 A:T[T>G]T 161.755 E:T[T>G]T 152.132 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Biliary-AdenoCA SBS12 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3696.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS12 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3696.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS12 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3696.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS12 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3696.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS12 T>C 1782.0 1914.0 1871.1 1826.15 0.04065739810999824 0.13008755833552949 100.0 3696.0 Leading 1.074 0.976 1.101 1 1782.0 1871.1 1796.0 1950.0 [1864.0, 1796.0, 1866.0, 1827.0, 1874.0, 1844.0, 1885.0, 1924.0, 1907.0, 1922.0, 1950.0, 1876.0, 1880.0, 1877.0, 1874.0, 1886.0, 1854.0, 1906.0, 1851.0, 1914.0, 1801.0, 1902.0, 1858.0, 1830.0, 1841.0, 1833.0, 1881.0, 1901.0, 1845.0, 1888.0, 1829.0, 1830.0, 1936.0, 1898.0, 1885.0, 1830.0, 1902.0, 1856.0, 1865.0, 1878.0, 1865.0, 1946.0, 1884.0, 1856.0, 1878.0, 1863.0, 1906.0, 1924.0, 1847.0, 1819.0, 1858.0, 1840.0, 1914.0, 1899.0, 1868.0, 1824.0, 1852.0, 1875.0, 1885.0, 1832.0, 1845.0, 1905.0, 1852.0, 1865.0, 1922.0, 1875.0, 1869.0, 1882.0, 1874.0, 1875.0, 1895.0, 1865.0, 1878.0, 1910.0, 1840.0, 1860.0, 1898.0, 1859.0, 1847.0, 1871.0, 1855.0, 1855.0, 1883.0, 1888.0, 1830.0, 1877.0, 1864.0, 1851.0, 1813.0, 1870.0, 1876.0, 1895.0, 1844.0, 1870.0, 1894.0, 1871.0, 1855.0, 1884.0, 1905.0, 1842.0] 1914.0 1826.15 1743.0 1905.0 [1835.0, 1892.0, 1834.0, 1842.0, 1833.0, 1854.0, 1819.0, 1778.0, 1805.0, 1764.0, 1743.0, 1820.0, 1833.0, 1827.0, 1809.0, 1812.0, 1831.0, 1809.0, 1849.0, 1779.0, 1869.0, 1815.0, 1797.0, 1860.0, 1856.0, 1849.0, 1797.0, 1806.0, 1854.0, 1822.0, 1874.0, 1884.0, 1751.0, 1794.0, 1810.0, 1870.0, 1844.0, 1800.0, 1822.0, 1822.0, 1840.0, 1748.0, 1848.0, 1867.0, 1814.0, 1845.0, 1799.0, 1779.0, 1867.0, 1866.0, 1829.0, 1859.0, 1804.0, 1810.0, 1856.0, 1864.0, 1850.0, 1853.0, 1820.0, 1841.0, 1865.0, 1794.0, 1821.0, 1831.0, 1772.0, 1801.0, 1840.0, 1810.0, 1838.0, 1844.0, 1798.0, 1828.0, 1785.0, 1776.0, 1850.0, 1833.0, 1790.0, 1842.0, 1835.0, 1806.0, 1844.0, 1821.0, 1816.0, 1821.0, 1858.0, 1840.0, 1840.0, 1847.0, 1905.0, 1837.0, 1813.0, 1841.0, 1860.0, 1823.0, 1792.0, 1831.0, 1836.0, 1809.0, 1785.0, 1814.0] Biliary-AdenoCA SBS12 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3696.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] ESCC SBS12 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6295.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS12 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6295.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS12 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6295.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS12 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6295.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS12 T>C 3604.0 2691.0 3203.9 3130.44 5.549297283373238e-14 3.974183054461404e-13 100.0 6295.0 Lagging 1.339 1.023 1.309 1 1 1 3604.0 3203.9 3104.0 3286.0 [3227, 3262, 3116, 3202, 3200, 3214, 3259, 3206, 3229, 3184, 3254, 3207, 3193, 3235, 3235, 3266, 3141, 3280, 3171, 3194, 3194, 3237, 3104, 3183, 3231, 3185, 3208, 3193, 3215, 3213, 3196, 3209, 3196, 3115, 3286, 3222, 3225, 3177, 3134, 3218, 3189, 3222, 3255, 3200, 3249, 3214, 3169, 3184, 3115, 3205, 3246, 3172, 3173, 3277, 3231, 3205, 3196, 3215, 3274, 3207, 3182, 3194, 3223, 3240, 3255, 3137, 3268, 3235, 3191, 3253, 3258, 3165, 3131, 3183, 3217, 3228, 3205, 3227, 3269, 3144, 3200, 3192, 3163, 3273, 3214, 3123, 3225, 3194, 3225, 3158, 3186, 3146, 3196, 3147, 3167, 3182, 3142, 3240, 3218, 3180] 2691.0 3130.44 3035.0 3229.0 [3114, 3058, 3215, 3167, 3145, 3148, 3084, 3145, 3103, 3190, 3132, 3104, 3132, 3094, 3085, 3086, 3190, 3037, 3229, 3097, 3157, 3088, 3215, 3135, 3129, 3112, 3107, 3120, 3093, 3148, 3123, 3182, 3135, 3213, 3050, 3139, 3090, 3133, 3209, 3116, 3145, 3085, 3035, 3100, 3094, 3101, 3143, 3125, 3175, 3130, 3077, 3168, 3141, 3085, 3106, 3128, 3149, 3093, 3060, 3121, 3132, 3144, 3118, 3083, 3076, 3196, 3076, 3082, 3164, 3119, 3102, 3164, 3186, 3161, 3118, 3138, 3142, 3135, 3118, 3209, 3115, 3120, 3134, 3065, 3168, 3188, 3135, 3139, 3087, 3158, 3109, 3150, 3125, 3200, 3197, 3161, 3214, 3116, 3104, 3186] ESCC SBS12 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6295.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Kidney-RCC SBS12 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2054.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Kidney-RCC SBS12 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2054.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Kidney-RCC SBS12 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2054.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Kidney-RCC SBS12 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2054.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Kidney-RCC SBS12 T>C 993.0 1061.0 1038.32 1012.58 0.1509440741454227 0.3980907775769947 100.0 2054.0 Leading 1.068 0.975 1.096 1 993.0 1038.32 981.0 1111.0 [1019, 1050, 1017, 1002, 983, 1111, 1025, 1044, 1020, 1089, 1036, 1061, 1050, 1040, 1055, 1049, 1070, 1016, 1020, 1018, 1016, 1089, 1008, 1036, 1060, 1046, 1110, 1062, 1013, 1018, 1030, 1039, 1089, 1090, 1049, 1088, 1008, 985, 1045, 984, 1027, 993, 1026, 1058, 1039, 1028, 1044, 1020, 981, 1054, 1049, 1036, 1035, 1073, 983, 1028, 996, 1093, 1059, 1061, 1063, 1042, 1041, 1018, 1061, 1053, 1034, 1019, 1021, 1029, 1041, 1003, 1038, 1025, 1049, 1033, 1044, 1064, 1093, 1014, 999, 1028, 1012, 1055, 1042, 1045, 992, 1065, 1009, 997, 992, 1057, 1065, 1036, 1072, 1074, 1012, 1045, 1080, 1047] 1061.0 1012.58 939.0 1065.0 [1004, 990, 1020, 1032, 1062, 951, 1020, 1007, 1016, 977, 1032, 998, 1015, 1000, 1010, 1034, 987, 1001, 1037, 1037, 1046, 980, 1030, 1012, 1002, 1021, 939, 982, 1036, 1035, 1001, 1013, 984, 961, 1005, 970, 1030, 1054, 1007, 1052, 1018, 1058, 1001, 1005, 1000, 1025, 1005, 1023, 1056, 993, 993, 1004, 1023, 982, 1046, 1022, 1037, 951, 994, 993, 991, 1018, 1013, 1035, 987, 1007, 1013, 1037, 1028, 1030, 1018, 1026, 1028, 1028, 991, 1047, 1012, 990, 958, 1013, 1065, 1015, 1053, 1012, 988, 1008, 1054, 982, 1049, 1048, 1034, 983, 1009, 1021, 985, 992, 1048, 1024, 990, 1009] Kidney-RCC SBS12 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2054.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS12 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 50754.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS12 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 50754.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS12 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 50754.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS12 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 50754.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS12 T>C 24541.0 26213.0 25809.11 25222.03 1.3952874502601975e-12 9.556450591145752e-12 100.0 50754.0 Leading 1.068 0.977 1.093 24541.0 25809.11 25591.0 26101.0 [26087, 25855, 25828, 25760, 25870, 25671, 25807, 25835, 25788, 25591, 25959, 25835, 25993, 25852, 25874, 25676, 25939, 25876, 25938, 25812, 25675, 26101, 25899, 25772, 25851, 25987, 25861, 25771, 25687, 25904, 25807, 25729, 25850, 25897, 25849, 25778, 25605, 25896, 25741, 25719, 25884, 25698, 25967, 25887, 25829, 25877, 25740, 25829, 25602, 25771, 25759, 25820, 25779, 26035, 25777, 25821, 25877, 25766, 26015, 25736, 25735, 25760, 25706, 25818, 25806, 25651, 25706, 25859, 25920, 25724, 25732, 25830, 25803, 25813, 25811, 25871, 25791, 25848, 25658, 25803, 25783, 25870, 25767, 25655, 25616, 25900, 26021, 25744, 25741, 25795, 25610, 25812, 25650, 25766, 25795, 25839, 25822, 25718, 25683, 25985] 26213.0 25222.03 25002.0 25443.0 [25002, 25184, 25072, 25220, 25168, 25282, 25208, 25277, 25189, 25362, 25132, 25140, 25071, 25154, 25135, 25310, 25162, 25073, 25115, 25072, 25347, 25125, 25192, 25293, 25080, 25055, 25165, 25364, 25372, 25056, 25213, 25317, 25268, 25142, 25177, 25225, 25367, 25164, 25285, 25304, 25114, 25195, 25088, 25160, 25100, 25235, 25215, 25101, 25322, 25186, 25205, 25213, 25118, 25074, 25292, 25251, 25203, 25333, 25059, 25270, 25250, 25262, 25382, 25245, 25344, 25441, 25303, 25311, 25146, 25319, 25350, 25172, 25249, 25136, 25227, 25087, 25234, 25199, 25391, 25340, 25269, 25237, 25271, 25225, 25361, 25107, 25095, 25272, 25365, 25217, 25443, 25213, 25405, 25383, 25248, 25228, 25233, 25302, 25323, 25045] Liver-HCC SBS12 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 50754.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS12 T>C Lagging ['ESCC'] 1 ['ESCC'] 1 ['ESCC'] 1 [] 0 [] 0 [] 0 ['Biliary-AdenoCA', 'ESCC', 'Kidney-RCC', 'Liver-HCC'] 4 1.3 SBS12 T>C Leading [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['Biliary-AdenoCA', 'ESCC', 'Kidney-RCC', 'Liver-HCC'] 4