# Only cancer types with minimum 2000 mutations for SBS signatures with average probability at least 0.75 are considered. signature cancer_type processive_group_length number_of_processive_groups log10_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_number_of_processive_groups SBS12 Kidney-RCC 2 4 1.386 0.48 1.0 5.0 2.461 1.2 0.10227863245462733 0.1329622221910155 0.876 [2, 2, 2, 3, 2, 2, 2, 5, 4, 2, 1, 3, 2, 4, 2, 2, 2, 4, 1, 4, 1, 3, 3, 4, 2, 3, 1, 4, 1, 4, 1, 1, 1, 2, 2, 2, 4, 2, 2, 3, 5, 2, 5, 1, 4, 4, 3, 5, 2, 3, 1, 2, 1, 2, 1, 3, 1, 5, 1, 3, 2, 1, 3, 2, 1, 2, 4, 2, 1, 3, 1, 1, 3, 2, 2, 4, 3, 1, 1, 3, 4, 3, 2, 5, 3, 2, 3, 1, 3] SBS12 Biliary-AdenoCA 2 31 1.491 0.48 14.0 34.0 23.56 4.196 0.039589076052514334 0.049486345065642916 1.306 [28, 17, 19, 26, 21, 20, 27, 20, 22, 19, 14, 23, 23, 21, 28, 24, 21, 25, 23, 25, 28, 27, 17, 26, 24, 21, 24, 19, 28, 30, 20, 23, 26, 33, 17, 28, 25, 15, 21, 20, 32, 30, 27, 18, 24, 25, 20, 22, 22, 22, 30, 27, 19, 23, 23, 20, 29, 19, 22, 23, 19, 25, 23, 27, 18, 25, 24, 30, 27, 34, 26, 21, 21, 25, 24, 21, 30, 26, 21, 30, 19, 19, 16, 28, 22, 18, 21, 30, 27, 19, 22, 26, 27, 30, 24, 21, 24, 27, 27, 17] SBS12 ESCC 2 89 4.489 0.48 46.0 84.0 64.37 8.084 0.0012789985735080162 0.0016927922296429627 2.771 [59, 62, 65, 78, 69, 70, 66, 78, 58, 60, 70, 56, 67, 61, 56, 69, 68, 68, 53, 60, 64, 51, 64, 57, 55, 64, 82, 54, 56, 46, 54, 64, 46, 71, 68, 61, 59, 62, 57, 58, 62, 64, 66, 55, 71, 74, 66, 74, 74, 75, 50, 71, 58, 64, 73, 54, 57, 60, 63, 62, 84, 65, 66, 57, 64, 64, 78, 79, 66, 60, 79, 62, 72, 73, 61, 55, 63, 71, 53, 65, 84, 60, 68, 56, 59, 81, 60, 67, 78, 64, 61, 60, 65, 60, 56, 67, 63, 69, 72, 71] SBS12 Liver-HCC 2 411 6.019 0.48 227.0 320.0 275.61 18.074 6.014410222102194e-14 1.1652919805323005e-13 12.934 [302, 248, 285, 320, 294, 272, 296, 277, 284, 246, 264, 294, 291, 260, 297, 275, 285, 282, 289, 267, 273, 305, 271, 291, 274, 277, 295, 231, 274, 262, 283, 274, 300, 262, 278, 287, 285, 276, 227, 280, 256, 265, 249, 284, 235, 285, 251, 273, 289, 253, 317, 296, 245, 288, 248, 287, 287, 274, 286, 282, 275, 276, 289, 250, 253, 252, 273, 276, 259, 273, 280, 296, 295, 294, 306, 277, 258, 250, 284, 289, 279, 279, 277, 256, 265, 264, 291, 261, 241, 289, 258, 275, 263, 284, 288, 281, 290, 253, 288, 291] SBS12 Liver-HCC 3 3 1.099 0.088 1.0 6.0 2.049 1.114 0.19951690816897816 0.19951690816897816 0.7 [3, 1, 2, 1, 2, 2, 1, 4, 2, 1, 3, 2, 1, 2, 3, 1, 3, 4, 1, 2, 1, 1, 1, 2, 2, 1, 4, 1, 2, 5, 1, 2, 2, 2, 1, 1, 4, 2, 2, 1, 1, 5, 2, 2, 1, 1, 1, 2, 4, 2, 2, 2, 1, 1, 3, 2, 2, 2, 3, 3, 1, 4, 3, 1, 2, 1, 1, 3, 2, 1, 1, 2, 3, 1, 3, 2, 3, 3, 1, 1, 2, 6] signature cancer_type processive_group_length avg_number_of_processive_groups log10_avg_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_avg_number_of_processive_groups SBS12 ACROSS_ALL_CANCER_TYPES 2 133.75 2.126 0.48 76.75 106.75 91.5 4.945 1.3419546415032086e-17 2.6839092830064172e-17 16.571 [97.75, 82.25, 92.75, 106.75, 96.5, 91.0, 97.75, 95.0, 92.0, 81.75, 87.25, 94.0, 95.75, 86.5, 95.75, 92.5, 94.0, 94.75, 91.5, 89.0, 91.5, 96.5, 88.75, 94.5, 88.75, 91.25, 100.5, 77.0, 89.75, 85.5, 89.5, 90.5, 93.25, 92.0, 91.25, 94.5, 93.25, 88.75, 76.75, 90.25, 88.75, 90.25, 86.75, 89.5, 83.5, 97.0, 85.0, 93.5, 96.75, 88.25, 99.5, 99.0, 80.75, 94.25, 86.25, 91.0, 93.5, 89.5, 93.0, 92.5, 95.0, 91.75, 95.25, 84.0, 84.0, 85.75, 94.75, 96.75, 88.25, 92.5, 96.5, 95.0, 97.75, 98.5, 98.25, 89.25, 88.5, 87.0, 89.75, 96.75, 96.5, 90.25, 90.75, 86.25, 87.25, 91.25, 93.75, 89.75, 87.25, 93.615, 85.865, 90.865, 89.365, 94.115, 92.615, 92.865, 94.865, 87.865, 97.365, 95.365] SBS12 ACROSS_ALL_CANCER_TYPES 3 3.0 0.477 0.108 1.0 6.0 2.049 1.114 0.19951690816897816 0.19951690816897816 0.7 [3.0, 1.0, 2.0, 1.0, 2.0, 2.0, 1.0, 4.0, 2.0, 1.0, 3.0, 2.0, 1.0, 2.0, 3.0, 1.0, 3.0, 4.0, 1.0, 2.0, 1.0, 1.0, 1.0, 2.0, 2.0, 1.0, 4.0, 1.0, 2.0, 5.0, 1.0, 2.0, 2.0, 2.0, 1.0, 1.0, 4.0, 2.0, 2.0, 1.0, 1.0, 5.0, 2.0, 2.0, 1.0, 1.0, 1.0, 2.0, 4.0, 2.0, 2.0, 2.0, 1.0, 1.0, 3.0, 2.0, 2.0, 2.0, 3.0, 3.0, 1.0, 4.0, 3.0, 1.0, 2.0, 1.0, 1.0, 3.0, 2.0, 1.0, 1.0, 2.0, 3.0, 1.0, 3.0, 2.0, 3.0, 3.0, 1.0, 1.0, 2.0, 6.0]