# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on lagging:A and leading:E strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
A:A[C>A]A	6.044
E:A[C>A]A	6.919
A:A[C>G]A	5.738
E:A[C>G]A	6.588
A:A[C>T]A	2551.919
E:A[C>T]A	2714.951
A:A[T>A]A	26.919
E:A[T>A]A	26.633
A:A[T>C]A	31.053
E:A[T>C]A	30.456
A:A[T>G]A	12.346
E:A[T>G]A	13.207
A:A[C>A]C	28.347
E:A[C>A]C	32.146
A:A[C>G]C	8.725
E:A[C>G]C	11.105
A:A[C>T]C	12367.958
E:A[C>T]C	12678.558
A:A[T>A]C	14.207
E:A[T>A]C	16.677
A:A[T>C]C	30.675
E:A[T>C]C	34.962
A:A[T>G]C	1.926
E:A[T>G]C	2.152
A:A[C>A]G	4.52
E:A[C>A]G	2.393
A:A[C>G]G	1.384
E:A[C>G]G	1.384
A:A[C>T]G	641.164
E:A[C>T]G	647.956
A:A[T>A]G	1.453
E:A[T>A]G	1.453
A:A[T>C]G	5.693
E:A[T>C]G	5.862
A:A[T>G]G	5.691
E:A[T>G]G	4.58
A:A[C>A]T	22.574
E:A[C>A]T	22.131
A:A[C>G]T	18.353
E:A[C>G]T	16.162
A:A[C>T]T	9487.387
E:A[C>T]T	9459.194
A:A[T>A]T	0.288
E:A[T>A]T	0.312
A:A[T>C]T	38.764
E:A[T>C]T	36.06
A:A[T>G]T	11.846
E:A[T>G]T	11.846
A:C[C>A]A	37.207
E:C[C>A]A	40.184
A:C[C>G]A	6.957
E:C[C>G]A	6.324
A:C[C>T]A	1607.695
E:C[C>T]A	1598.73
A:C[T>A]A	11.111
E:C[T>A]A	11.653
A:C[T>C]A	9.413
E:C[T>C]A	10.011
A:C[T>G]A	0.0
E:C[T>G]A	0.0
A:C[C>A]C	53.607
E:C[C>A]C	59.976
A:C[C>G]C	4.403
E:C[C>G]C	4.403
A:C[C>T]C	13040.959
E:C[C>T]C	13359.294
A:C[T>A]C	12.142
E:C[T>A]C	11.692
A:C[T>C]C	35.42
E:C[T>C]C	30.87
A:C[T>G]C	0.0
E:C[T>G]C	0.0
A:C[C>A]G	0.149
E:C[C>A]G	0.168
A:C[C>G]G	0.093
E:C[C>G]G	0.124
A:C[C>T]G	110.662
E:C[C>T]G	109.135
A:C[T>A]G	20.234
E:C[T>A]G	15.402
A:C[T>C]G	2.145
E:C[T>C]G	2.145
A:C[T>G]G	0.0
E:C[T>G]G	0.0
A:C[C>A]T	18.125
E:C[C>A]T	17.275
A:C[C>G]T	0.28
E:C[C>G]T	0.308
A:C[C>T]T	8992.891
E:C[C>T]T	8991.938
A:C[T>A]T	14.19
E:C[T>A]T	15.461
A:C[T>C]T	3.466
E:C[T>C]T	3.388
A:C[T>G]T	3.446
E:C[T>G]T	3.101
A:G[C>A]A	6.281
E:G[C>A]A	5.251
A:G[C>G]A	1.331
E:G[C>G]A	1.397
A:G[C>T]A	2454.204
E:G[C>T]A	2450.694
A:G[T>A]A	0.063
E:G[T>A]A	0.06
A:G[T>C]A	65.383
E:G[T>C]A	60.176
A:G[T>G]A	1.704
E:G[T>G]A	1.491
A:G[C>A]C	20.252
E:G[C>A]C	18.61
A:G[C>G]C	4.418
E:G[C>G]C	4.004
A:G[C>T]C	10125.217
E:G[C>T]C	10262.637
A:G[T>A]C	11.969
E:G[T>A]C	12.927
A:G[T>C]C	56.705
E:G[T>C]C	60.168
A:G[T>G]C	0.0
E:G[T>G]C	0.0
A:G[C>A]G	0.201
E:G[C>A]G	0.201
A:G[C>G]G	0.03
E:G[C>G]G	0.075
A:G[C>T]G	269.781
E:G[C>T]G	262.828
A:G[T>A]G	3.259
E:G[T>A]G	4.802
A:G[T>C]G	17.698
E:G[T>C]G	17.909
A:G[T>G]G	2.685
E:G[T>G]G	3.729
A:G[C>A]T	0.0
E:G[C>A]T	0.0
A:G[C>G]T	5.611
E:G[C>G]T	5.446
A:G[C>T]T	7072.857
E:G[C>T]T	6805.866
A:G[T>A]T	11.422
E:G[T>A]T	13.281
A:G[T>C]T	15.812
E:G[T>C]T	17.239
A:G[T>G]T	11.443
E:G[T>G]T	7.947
A:T[C>A]A	10.688
E:T[C>A]A	11.672
A:T[C>G]A	1.055
E:T[C>G]A	0.83
A:T[C>T]A	2430.886
E:T[C>T]A	2535.432
A:T[T>A]A	9.809
E:T[T>A]A	10.973
A:T[T>C]A	4.505
E:T[T>C]A	4.248
A:T[T>G]A	3.753
E:T[T>G]A	3.649
A:T[C>A]C	55.687
E:T[C>A]C	59.874
A:T[C>G]C	10.604
E:T[C>G]C	12.516
A:T[C>T]C	15989.361
E:T[C>T]C	16147.138
A:T[T>A]C	11.117
E:T[T>A]C	12.927
A:T[T>C]C	24.463
E:T[T>C]C	26.733
A:T[T>G]C	1.981
E:T[T>G]C	2.049
A:T[C>A]G	0.0
E:T[C>A]G	0.0
A:T[C>G]G	0.0
E:T[C>G]G	0.0
A:T[C>T]G	0.051
E:T[C>T]G	0.05
A:T[T>A]G	8.054
E:T[T>A]G	8.974
A:T[T>C]G	3.992
E:T[T>C]G	4.151
A:T[T>G]G	2.901
E:T[T>G]G	3.743
A:T[C>A]T	3.016
E:T[C>A]T	2.574
A:T[C>G]T	11.558
E:T[C>G]T	10.603
A:T[C>T]T	12739.721
E:T[C>T]T	12670.419
A:T[T>A]T	40.781
E:T[T>A]T	43.594
A:T[T>C]T	4.949
E:T[T>C]T	4.601
A:T[T>G]T	2.112
E:T[T>G]T	2.083

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Lagging_real_count	Leading_real_count	Lagging_mean_sims_count	Leading_mean_sims_count	lagging_versus_leading_p_value	lagging_versus_leading_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Lagging_real_count.1	Lagging_mean_sims_count.1	Lagging_min_sims_count	Lagging_max_sims_count	Lagging_sims_count_list	Leading_real_count.1	Leading_mean_sims_count.1	Leading_min_sims_count	Leading_max_sims_count	Leading_sims_count_list
CNS-GBM	SBS11	C>A	101.0	110.0	103.11	106.31	0.8452182848705673	1.0	0.1	211220.0	Leading	1.089	1.031	1.056							101.0	103.11	85.0	120.0	[93, 118, 112, 110, 108, 103, 108, 101, 112, 107, 111, 100, 107, 103, 100, 94, 120, 101, 102, 107, 107, 97, 102, 100, 103, 109, 108, 96, 116, 98, 89, 96, 96, 92, 114, 85, 92, 96, 111, 98, 102, 94, 100, 100, 104, 94, 101, 94, 91, 103, 109, 107, 99, 110, 113, 88, 105, 117, 105, 110, 106, 104, 88, 108, 97, 93, 107, 112, 103, 98, 103, 105, 102, 109, 110, 96, 112, 111, 88, 101, 104, 115, 112, 112, 102, 97, 101, 102, 113, 98, 89, 98, 101, 114, 105, 100, 97, 118, 97, 115]	110.0	106.31	89.0	125.0	[113, 95, 102, 103, 103, 104, 97, 107, 98, 105, 96, 117, 105, 112, 111, 117, 96, 113, 109, 101, 105, 115, 114, 110, 113, 98, 102, 103, 98, 108, 119, 109, 111, 116, 94, 117, 121, 109, 98, 115, 113, 114, 106, 99, 109, 117, 106, 114, 107, 98, 102, 104, 112, 97, 103, 125, 107, 95, 101, 97, 101, 110, 121, 102, 115, 115, 100, 103, 109, 107, 106, 98, 110, 101, 101, 109, 98, 95, 118, 105, 116, 89, 95, 102, 103, 115, 110, 112, 92, 111, 117, 110, 112, 95, 98, 108, 117, 90, 110, 100]
CNS-GBM	SBS11	C>G	0.0	0.0	0.0	0.0	1.0	1.0	0.0	211220.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
CNS-GBM	SBS11	C>T	104782.0	106227.0	105034.67	105832.87	0.31993448548708303	0.6993384178896568	99.9	211220.0	Leading	1.014	1.008	1.006							104782.0	105034.67	104506.0	105457.0	[105359, 104934, 104782, 104517, 104934, 105046, 104675, 105086, 104805, 105138, 105238, 105201, 105064, 105355, 104903, 105093, 104689, 104682, 105410, 104703, 105307, 104982, 104833, 104506, 105357, 105106, 104886, 104961, 105180, 104977, 104972, 105457, 105151, 105176, 105186, 105142, 105328, 105091, 105221, 104809, 104810, 105167, 105064, 105153, 105036, 105224, 105283, 104862, 105274, 105019, 105101, 104653, 104835, 104746, 105000, 104784, 104911, 105270, 105241, 105186, 104802, 105245, 104906, 105097, 105380, 104908, 104880, 105058, 104734, 104884, 104738, 105406, 104969, 104942, 104847, 105445, 105289, 105430, 105319, 105107, 104810, 105203, 105065, 105103, 105194, 105162, 104722, 104858, 104936, 104886, 105108, 105049, 105266, 105061, 105139, 105117, 105205, 104781, 104913, 104642]	106227.0	105832.87	105378.0	106411.0	[105666, 105801, 105894, 106384, 105850, 105942, 105857, 105848, 106078, 105862, 105655, 105689, 106001, 105559, 105922, 105711, 106165, 106330, 105650, 106219, 105520, 105902, 105795, 106411, 105378, 105864, 105848, 105966, 105693, 105782, 105729, 105387, 105738, 105769, 105551, 105893, 105705, 105999, 105843, 106087, 106026, 105695, 105875, 105784, 106005, 105697, 105825, 106104, 105420, 105751, 105616, 106091, 105773, 106131, 105701, 105763, 105840, 105537, 105783, 105736, 106202, 105718, 105876, 105886, 105490, 105837, 105843, 105599, 106351, 106029, 106060, 105673, 105751, 105717, 106099, 105595, 105471, 105595, 105675, 105897, 105787, 105640, 105579, 105772, 105837, 105980, 106262, 105892, 105833, 105811, 105795, 105914, 105664, 105745, 105875, 105756, 105588, 105917, 106005, 106175]
CNS-GBM	SBS11	T>A	0.0	0.0	0.0	0.0	1.0	1.0	0.0	211220.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
CNS-GBM	SBS11	T>C	0.0	0.0	0.0	0.0	1.0	1.0	0.0	211220.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
CNS-GBM	SBS11	T>G	0.0	0.0	0.0	0.0	1.0	1.0	0.0	211220.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change