# Only cancer types with minimum 2000 mutations for SBS signatures with average probability at least 0.75 are considered. signature cancer_type processive_group_length number_of_processive_groups log10_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_number_of_processive_groups SBS11 CNS-GBM 2 32660 10.394 0.48 32661.0 33386.0 33077.17 147.07 0.9975099510154262 0.9975099510154262 0.001 [32982, 33268, 32919, 32994, 32956, 33077, 33122, 33136, 33109, 33284, 33323, 33357, 33108, 33066, 33358, 32938, 33386, 32919, 32972, 32982, 32834, 33139, 33196, 33003, 32927, 33071, 32910, 32974, 32949, 32958, 32909, 32975, 33051, 33080, 33130, 33128, 32986, 33291, 33002, 32661, 33068, 33284, 32885, 33334, 33256, 33102, 33005, 33378, 33266, 33120, 33160, 33153, 32883, 33158, 32858, 32960, 33380, 33074, 33194, 33023, 33054, 33271, 33023, 32858, 32927, 33070, 33104, 32808, 33155, 33080, 33141, 33079, 32900, 32932, 32915, 32920, 33116, 33021, 32949, 33261, 33367, 33041, 33058, 33141, 33076, 32942, 32987, 33079, 33174, 32987, 33076, 33288, 33213, 33001, 33276, 32935, 33131, 33241, 33014, 33135] SBS11 CNS-GBM 3 9447 9.153 0.423 8911.0 9369.0 9168.7 82.415 0.0004140949749810708 0.0006023199636088302 3.22 [9199, 9369, 9148, 9117, 9119, 9203, 9157, 9233, 9207, 9195, 9167, 9215, 9279, 9213, 9119, 9068, 9058, 9079, 9180, 9186, 9255, 9076, 9149, 9323, 9247, 9070, 9198, 9177, 9128, 9253, 9104, 9225, 9225, 9256, 9062, 9027, 9189, 9188, 9240, 9333, 9196, 9032, 9116, 9181, 9047, 9311, 9265, 9061, 9229, 9141, 9126, 9221, 9140, 9046, 9344, 9310, 9222, 9106, 9058, 9155, 9201, 9114, 9191, 9145, 9086, 9218, 9195, 9186, 9012, 9084, 9151, 9149, 9204, 9184, 9126, 9296, 9250, 9254, 9182, 9213, 9154, 9047, 9160, 9225, 9132, 9154, 9161, 9214, 9003, 9238, 9059, 9114, 9202, 9194, 9244, 9243, 9184, 9029, 9218, 8911] SBS11 CNS-GBM 4 2904 7.974 0.368 2440.0 2668.0 2565.85 48.351 2.193667224893434e-12 5.849779266382491e-12 11.233 [2496, 2524, 2574, 2576, 2592, 2568, 2604, 2554, 2503, 2592, 2553, 2545, 2525, 2593, 2581, 2643, 2534, 2627, 2562, 2630, 2522, 2552, 2657, 2552, 2631, 2512, 2587, 2523, 2579, 2597, 2609, 2569, 2464, 2440, 2620, 2570, 2564, 2523, 2475, 2571, 2668, 2553, 2668, 2596, 2660, 2515, 2630, 2525, 2504, 2512, 2523, 2540, 2649, 2599, 2588, 2593, 2565, 2571, 2563, 2581, 2555, 2537, 2469, 2524, 2636, 2585, 2656, 2522, 2557, 2478, 2607, 2514, 2538, 2578, 2583, 2518, 2515, 2557, 2583, 2538, 2576, 2658, 2657, 2536, 2537, 2594, 2580, 2492, 2606, 2616, 2569, 2580, 2542, 2559, 2569, 2566, 2507, 2585, 2535, 2575] SBS11 CNS-GBM 5 893 6.795 0.314 672.0 795.0 730.48 24.296 1.7641961736341998e-11 4.0324483968781706e-11 10.394 [706, 734, 737, 727, 733, 713, 737, 714, 761, 751, 707, 705, 715, 689, 703, 758, 695, 773, 698, 736, 718, 731, 706, 756, 736, 691, 748, 756, 756, 732, 732, 733, 726, 748, 706, 698, 795, 724, 782, 727, 710, 703, 767, 709, 740, 740, 745, 725, 753, 716, 766, 708, 726, 707, 718, 672, 700, 725, 749, 733, 744, 705, 761, 766, 729, 760, 702, 737, 725, 768, 733, 792, 721, 733, 749, 696, 700, 750, 747, 689, 699, 745, 702, 722, 748, 741, 760, 740, 712, 745, 746, 731, 692, 738, 733, 753, 748, 744, 699, 738] SBS11 CNS-GBM 6 279 5.631 0.26 173.0 241.0 209.4 15.828 6.6970937451454215e-06 1.1905944435814082e-05 4.924 [230, 198, 232, 219, 190, 183, 223, 177, 216, 220, 215, 192, 208, 209, 201, 225, 208, 231, 229, 209, 224, 189, 192, 230, 213, 223, 210, 225, 200, 202, 195, 220, 217, 215, 241, 192, 203, 201, 223, 239, 193, 198, 229, 204, 204, 200, 192, 191, 224, 221, 215, 216, 208, 198, 209, 210, 222, 216, 208, 225, 195, 206, 233, 205, 210, 212, 182, 213, 198, 237, 182, 195, 241, 235, 211, 204, 193, 209, 173, 183, 187, 223, 196, 225, 208, 199, 178, 204, 228, 192, 222, 212, 208, 231, 208, 187, 205, 199, 220, 239] SBS11 CNS-GBM 7 93 4.533 0.209 45.0 79.0 60.78 7.406 8.269389039024924e-06 1.323102246243988e-05 4.878 [76, 66, 79, 55, 68, 67, 50, 59, 61, 57, 62, 67, 61, 56, 58, 67, 67, 64, 52, 57, 71, 76, 54, 56, 55, 52, 71, 54, 61, 62, 72, 56, 64, 59, 59, 65, 51, 53, 67, 54, 58, 63, 60, 55, 65, 58, 49, 62, 55, 63, 57, 55, 67, 65, 62, 63, 56, 58, 55, 63, 65, 47, 61, 72, 60, 59, 56, 58, 63, 72, 65, 57, 47, 70, 48, 69, 58, 77, 62, 60, 57, 69, 61, 65, 52, 54, 74, 47, 71, 62, 67, 54, 56, 45, 50, 61, 52, 63, 64, 78] SBS11 CNS-GBM 8 33 3.497 0.161 5.0 29.0 17.6 4.972 0.0010826373306911036 0.0014435164409214716 2.841 [5, 21, 17, 11, 16, 12, 12, 23, 14, 26, 24, 16, 16, 17, 25, 18, 16, 21, 23, 20, 14, 20, 20, 22, 17, 17, 17, 29, 17, 19, 22, 11, 13, 15, 27, 24, 13, 10, 20, 16, 15, 18, 12, 17, 14, 17, 10, 26, 21, 21, 11, 12, 22, 18, 18, 14, 14, 21, 28, 21, 15, 21, 14, 16, 17, 6, 16, 12, 24, 23, 17, 17, 21, 11, 27, 12, 21, 17, 25, 14, 16, 13, 23, 14, 15, 27, 23, 15, 15, 12, 13, 15, 20, 20, 10, 16, 28, 15, 21, 17] SBS11 CNS-GBM 9 19 2.944 0.136 1.0 12.0 5.09 2.159 8.955266405102805e-11 1.791053281020561e-10 9.747 [5, 4, 7, 5, 1, 7, 7, 6, 5, 4, 6, 4, 7, 5, 8, 3, 6, 4, 5, 4, 4, 4, 3, 3, 6, 8, 5, 8, 3, 4, 7, 4, 1, 5, 3, 11, 4, 3, 5, 10, 5, 8, 4, 5, 5, 4, 4, 8, 4, 8, 12, 3, 6, 1, 7, 3, 6, 6, 6, 2, 5, 4, 2, 6, 5, 5, 5, 8, 6, 6, 5, 7, 4, 7, 3, 6, 4, 4, 5, 6, 3, 8, 3, 7, 10, 5, 4, 7, 5, 1, 3, 5, 6, 10, 2, 2, 4, 5, 2, 3] SBS11 CNS-GBM 10 5 1.609 0.074 1.0 7.0 1.974 1.287 0.010167003771793436 0.01161943288204964 1.935 [4, 1, 3, 4, 2, 2, 3, 3, 3, 4, 4, 2, 2, 1, 2, 1, 4, 7, 1, 1, 2, 2, 1, 1, 3, 1, 1, 2, 3, 2, 1, 1, 1, 1, 3, 1, 1, 1, 1, 1, 2, 3, 1, 2, 3, 2, 2, 1, 5, 2, 1, 2, 6, 2, 1, 1, 1, 1, 1, 1, 1, 3, 2, 1, 1, 1, 5, 1, 2, 1, 1, 1, 2, 1, 2, 1] SBS11 CNS-GBM 11 1 0.0 0.0 1.0 2.0 1.086 0.28 0.616980312147447 0.6581123329572768 0.182 [1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1] SBS11 CNS-GBM 13 1 0.0 0.0 1.0 1.0 1.0 0.0 inf [1, 1, 1, 1, 1] signature cancer_type processive_group_length avg_number_of_processive_groups log10_avg_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_avg_number_of_processive_groups SBS11 ACROSS_ALL_CANCER_TYPES 10 5.0 0.699 0.074 1.0 7.0 1.974 1.287 0.010167003771793436 0.012708754714741794 1.896 [4.0, 1.0, 3.0, 4.0, 2.0, 2.0, 3.0, 3.0, 3.0, 4.0, 4.0, 2.0, 2.0, 1.0, 2.0, 1.0, 4.0, 7.0, 1.0, 1.0, 2.0, 2.0, 1.0, 1.0, 3.0, 1.0, 1.0, 2.0, 3.0, 2.0, 1.0, 1.0, 1.0, 1.0, 3.0, 1.0, 1.0, 1.0, 1.0, 1.0, 2.0, 3.0, 1.0, 2.0, 3.0, 2.0, 2.0, 1.0, 5.0, 2.0, 1.0, 2.0, 6.0, 2.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 3.0, 2.0, 1.0, 1.0, 1.0, 5.0, 1.0, 2.0, 1.0, 1.0, 1.0, 2.0, 1.0, 2.0, 1.0] SBS11 ACROSS_ALL_CANCER_TYPES 11 1.0 0.0 0.0 1.0 2.0 1.086 0.28 0.616980312147447 0.68553368016383 0.164 [1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 2.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 2.0, 1.0, 1.0, 1.0, 1.0, 1.0, 2.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0] SBS11 ACROSS_ALL_CANCER_TYPES 13 1.0 0.0 0.0 1.0 1.0 1.0 0.0 inf [1.0, 1.0, 1.0, 1.0, 1.0] SBS11 ACROSS_ALL_CANCER_TYPES 2 32660.0 4.514 0.48 32661.0 33386.0 33077.17 147.07 0.9975099510154262 0.9975099510154262 0.001 [32982.0, 33268.0, 32919.0, 32994.0, 32956.0, 33077.0, 33122.0, 33136.0, 33109.0, 33284.0, 33323.0, 33357.0, 33108.0, 33066.0, 33358.0, 32938.0, 33386.0, 32919.0, 32972.0, 32982.0, 32834.0, 33139.0, 33196.0, 33003.0, 32927.0, 33071.0, 32910.0, 32974.0, 32949.0, 32958.0, 32909.0, 32975.0, 33051.0, 33080.0, 33130.0, 33128.0, 32986.0, 33291.0, 33002.0, 32661.0, 33068.0, 33284.0, 32885.0, 33334.0, 33256.0, 33102.0, 33005.0, 33378.0, 33266.0, 33120.0, 33160.0, 33153.0, 32883.0, 33158.0, 32858.0, 32960.0, 33380.0, 33074.0, 33194.0, 33023.0, 33054.0, 33271.0, 33023.0, 32858.0, 32927.0, 33070.0, 33104.0, 32808.0, 33155.0, 33080.0, 33141.0, 33079.0, 32900.0, 32932.0, 32915.0, 32920.0, 33116.0, 33021.0, 32949.0, 33261.0, 33367.0, 33041.0, 33058.0, 33141.0, 33076.0, 32942.0, 32987.0, 33079.0, 33174.0, 32987.0, 33076.0, 33288.0, 33213.0, 33001.0, 33276.0, 32935.0, 33131.0, 33241.0, 33014.0, 33135.0] SBS11 ACROSS_ALL_CANCER_TYPES 3 9447.0 3.975 0.423 8911.0 9369.0 9168.7 82.415 0.0004140949749810708 0.000690158291635118 3.161 [9199.0, 9369.0, 9148.0, 9117.0, 9119.0, 9203.0, 9157.0, 9233.0, 9207.0, 9195.0, 9167.0, 9215.0, 9279.0, 9213.0, 9119.0, 9068.0, 9058.0, 9079.0, 9180.0, 9186.0, 9255.0, 9076.0, 9149.0, 9323.0, 9247.0, 9070.0, 9198.0, 9177.0, 9128.0, 9253.0, 9104.0, 9225.0, 9225.0, 9256.0, 9062.0, 9027.0, 9189.0, 9188.0, 9240.0, 9333.0, 9196.0, 9032.0, 9116.0, 9181.0, 9047.0, 9311.0, 9265.0, 9061.0, 9229.0, 9141.0, 9126.0, 9221.0, 9140.0, 9046.0, 9344.0, 9310.0, 9222.0, 9106.0, 9058.0, 9155.0, 9201.0, 9114.0, 9191.0, 9145.0, 9086.0, 9218.0, 9195.0, 9186.0, 9012.0, 9084.0, 9151.0, 9149.0, 9204.0, 9184.0, 9126.0, 9296.0, 9250.0, 9254.0, 9182.0, 9213.0, 9154.0, 9047.0, 9160.0, 9225.0, 9132.0, 9154.0, 9161.0, 9214.0, 9003.0, 9238.0, 9059.0, 9114.0, 9202.0, 9194.0, 9244.0, 9243.0, 9184.0, 9029.0, 9218.0, 8911.0] SBS11 ACROSS_ALL_CANCER_TYPES 4 2904.0 3.463 0.368 2440.0 2668.0 2565.85 48.351 2.193667224893434e-12 2.193667224893434e-11 10.659 [2496.0, 2524.0, 2574.0, 2576.0, 2592.0, 2568.0, 2604.0, 2554.0, 2503.0, 2592.0, 2553.0, 2545.0, 2525.0, 2593.0, 2581.0, 2643.0, 2534.0, 2627.0, 2562.0, 2630.0, 2522.0, 2552.0, 2657.0, 2552.0, 2631.0, 2512.0, 2587.0, 2523.0, 2579.0, 2597.0, 2609.0, 2569.0, 2464.0, 2440.0, 2620.0, 2570.0, 2564.0, 2523.0, 2475.0, 2571.0, 2668.0, 2553.0, 2668.0, 2596.0, 2660.0, 2515.0, 2630.0, 2525.0, 2504.0, 2512.0, 2523.0, 2540.0, 2649.0, 2599.0, 2588.0, 2593.0, 2565.0, 2571.0, 2563.0, 2581.0, 2555.0, 2537.0, 2469.0, 2524.0, 2636.0, 2585.0, 2656.0, 2522.0, 2557.0, 2478.0, 2607.0, 2514.0, 2538.0, 2578.0, 2583.0, 2518.0, 2515.0, 2557.0, 2583.0, 2538.0, 2576.0, 2658.0, 2657.0, 2536.0, 2537.0, 2594.0, 2580.0, 2492.0, 2606.0, 2616.0, 2569.0, 2580.0, 2542.0, 2559.0, 2569.0, 2566.0, 2507.0, 2585.0, 2535.0, 2575.0] SBS11 ACROSS_ALL_CANCER_TYPES 5 893.0 2.951 0.314 672.0 795.0 730.48 24.296 1.7641961736341994e-11 8.820980868170997e-11 10.054 [706.0, 734.0, 737.0, 727.0, 733.0, 713.0, 737.0, 714.0, 761.0, 751.0, 707.0, 705.0, 715.0, 689.0, 703.0, 758.0, 695.0, 773.0, 698.0, 736.0, 718.0, 731.0, 706.0, 756.0, 736.0, 691.0, 748.0, 756.0, 756.0, 732.0, 732.0, 733.0, 726.0, 748.0, 706.0, 698.0, 795.0, 724.0, 782.0, 727.0, 710.0, 703.0, 767.0, 709.0, 740.0, 740.0, 745.0, 725.0, 753.0, 716.0, 766.0, 708.0, 726.0, 707.0, 718.0, 672.0, 700.0, 725.0, 749.0, 733.0, 744.0, 705.0, 761.0, 766.0, 729.0, 760.0, 702.0, 737.0, 725.0, 768.0, 733.0, 792.0, 721.0, 733.0, 749.0, 696.0, 700.0, 750.0, 747.0, 689.0, 699.0, 745.0, 702.0, 722.0, 748.0, 741.0, 760.0, 740.0, 712.0, 745.0, 746.0, 731.0, 692.0, 738.0, 733.0, 753.0, 748.0, 744.0, 699.0, 738.0] SBS11 ACROSS_ALL_CANCER_TYPES 6 279.0 2.446 0.26 173.0 241.0 209.4 15.828 6.6970937451454215e-06 1.653877807804985e-05 4.781 [230.0, 198.0, 232.0, 219.0, 190.0, 183.0, 223.0, 177.0, 216.0, 220.0, 215.0, 192.0, 208.0, 209.0, 201.0, 225.0, 208.0, 231.0, 229.0, 209.0, 224.0, 189.0, 192.0, 230.0, 213.0, 223.0, 210.0, 225.0, 200.0, 202.0, 195.0, 220.0, 217.0, 215.0, 241.0, 192.0, 203.0, 201.0, 223.0, 239.0, 193.0, 198.0, 229.0, 204.0, 204.0, 200.0, 192.0, 191.0, 224.0, 221.0, 215.0, 216.0, 208.0, 198.0, 209.0, 210.0, 222.0, 216.0, 208.0, 225.0, 195.0, 206.0, 233.0, 205.0, 210.0, 212.0, 182.0, 213.0, 198.0, 237.0, 182.0, 195.0, 241.0, 235.0, 211.0, 204.0, 193.0, 209.0, 173.0, 183.0, 187.0, 223.0, 196.0, 225.0, 208.0, 199.0, 178.0, 204.0, 228.0, 192.0, 222.0, 212.0, 208.0, 231.0, 208.0, 187.0, 205.0, 199.0, 220.0, 239.0] SBS11 ACROSS_ALL_CANCER_TYPES 7 93.0 1.968 0.209 45.0 79.0 60.78 7.406 8.269389039024924e-06 1.653877807804985e-05 4.781 [76.0, 66.0, 79.0, 55.0, 68.0, 67.0, 50.0, 59.0, 61.0, 57.0, 62.0, 67.0, 61.0, 56.0, 58.0, 67.0, 67.0, 64.0, 52.0, 57.0, 71.0, 76.0, 54.0, 56.0, 55.0, 52.0, 71.0, 54.0, 61.0, 62.0, 72.0, 56.0, 64.0, 59.0, 59.0, 65.0, 51.0, 53.0, 67.0, 54.0, 58.0, 63.0, 60.0, 55.0, 65.0, 58.0, 49.0, 62.0, 55.0, 63.0, 57.0, 55.0, 67.0, 65.0, 62.0, 63.0, 56.0, 58.0, 55.0, 63.0, 65.0, 47.0, 61.0, 72.0, 60.0, 59.0, 56.0, 58.0, 63.0, 72.0, 65.0, 57.0, 47.0, 70.0, 48.0, 69.0, 58.0, 77.0, 62.0, 60.0, 57.0, 69.0, 61.0, 65.0, 52.0, 54.0, 74.0, 47.0, 71.0, 62.0, 67.0, 54.0, 56.0, 45.0, 50.0, 61.0, 52.0, 63.0, 64.0, 78.0] SBS11 ACROSS_ALL_CANCER_TYPES 8 33.0 1.519 0.161 5.0 29.0 17.6 4.972 0.0010826373306911038 0.0015466247581301484 2.811 [5.0, 21.0, 17.0, 11.0, 16.0, 12.0, 12.0, 23.0, 14.0, 26.0, 24.0, 16.0, 16.0, 17.0, 25.0, 18.0, 16.0, 21.0, 23.0, 20.0, 14.0, 20.0, 20.0, 22.0, 17.0, 17.0, 17.0, 29.0, 17.0, 19.0, 22.0, 11.0, 13.0, 15.0, 27.0, 24.0, 13.0, 10.0, 20.0, 16.0, 15.0, 18.0, 12.0, 17.0, 14.0, 17.0, 10.0, 26.0, 21.0, 21.0, 11.0, 12.0, 22.0, 18.0, 18.0, 14.0, 14.0, 21.0, 28.0, 21.0, 15.0, 21.0, 14.0, 16.0, 17.0, 6.0, 16.0, 12.0, 24.0, 23.0, 17.0, 17.0, 21.0, 11.0, 27.0, 12.0, 21.0, 17.0, 25.0, 14.0, 16.0, 13.0, 23.0, 14.0, 15.0, 27.0, 23.0, 15.0, 15.0, 12.0, 13.0, 15.0, 20.0, 20.0, 10.0, 16.0, 28.0, 15.0, 21.0, 17.0] SBS11 ACROSS_ALL_CANCER_TYPES 9 19.0 1.279 0.136 1.0 12.0 5.09 2.159 8.955266405102804e-11 2.9850888017009347e-10 9.525 [5.0, 4.0, 7.0, 5.0, 1.0, 7.0, 7.0, 6.0, 5.0, 4.0, 6.0, 4.0, 7.0, 5.0, 8.0, 3.0, 6.0, 4.0, 5.0, 4.0, 4.0, 4.0, 3.0, 3.0, 6.0, 8.0, 5.0, 8.0, 3.0, 4.0, 7.0, 4.0, 1.0, 5.0, 3.0, 11.0, 4.0, 3.0, 5.0, 10.0, 5.0, 8.0, 4.0, 5.0, 5.0, 4.0, 4.0, 8.0, 4.0, 8.0, 12.0, 3.0, 6.0, 1.0, 7.0, 3.0, 6.0, 6.0, 6.0, 2.0, 5.0, 4.0, 2.0, 6.0, 5.0, 5.0, 5.0, 8.0, 6.0, 6.0, 5.0, 7.0, 4.0, 7.0, 3.0, 6.0, 4.0, 4.0, 5.0, 6.0, 3.0, 8.0, 3.0, 7.0, 10.0, 5.0, 4.0, 7.0, 5.0, 1.0, 3.0, 5.0, 6.0, 10.0, 2.0, 2.0, 4.0, 5.0, 2.0, 3.0]